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Synaptic inhibition tunes contrast computation in the retina

Published online by Cambridge University Press:  20 May 2019

Nicholas W. Oesch  and
Jeffrey S. Diamond
Nicholas W. Oesch
Affiliation:
Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-3701
Jeffrey S. Diamond*
Affiliation:
Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-3701
*
*Address correspondence to: Jeffrey S. Diamond, Email: [email protected]
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Abstract

Inhibition shapes activity and signal processing in neural networks through numerous mechanisms mediated by many different cell types. Here, we examined how one type of GABAergic interneuron in the retina, the A17 amacrine cell, influences visual information processing. Our results suggest that A17s, which make reciprocal feedback inhibitory synapses onto rod bipolar cell (RBC) synaptic terminals, extend the luminance range over which RBC synapses compute temporal contrast and enhance the reliability of contrast signals over this range. Inhibition from other amacrine cells does not influence these computational features. Although A17-mediated feedback is mediated by both GABAA and GABAC receptors, the latter plays the primary role in extending the range of contrast computation. These results identify specific functions for an inhibitory interneuron subtype, as well as specific synaptic receptors, in a behaviorally relevant neural computation.

Keywords

Amacrine cellWeber contrastRibbon synapseFeedback inhibition
Type
Research Article
Information
Visual Neuroscience , Volume 36 , 2019 , E006
Copyright
Copyright © Cambridge University Press 2019 

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Footnotes

†

Present address: University of California, San Diego, Department of Psychology, Department of Ophthalmology, 9500 Gilman Drive MC#0109, La Jolla, California.

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