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The perihypoglossal projection to the superior colliculus in the rhesus monkey

Published online by Cambridge University Press:  02 June 2009

Rosi Hartwich-Young ,
Jon S. Nelson  and
David L. Sparks
Rosi Hartwich-Young
Affiliation:
Alcon Laboratories, Inc., Fort Worth
Jon S. Nelson
Affiliation:
Department of Physical Therapy, College of St. Scholastica, Duluth
David L. Sparks
Affiliation:
Department of Psychology, University of Pennsylvania, Philadelphia
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Abstract

The projection of the perihypoglossal (PH) complex to the superior colliculus (SC) in the rhesus monkey was investigated using the retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP). Following physiological identification by electrical stimulation and multiunit recording, small injections of the tracer were placed within the SC of three monkeys. The largest numbers of retrogradely labeled neurons within the PH complex were found in the contralateral nucleus prepositus hypoglossi (NPH), in the laterally adjacent medial vestibular nucleus, and in the ventrally adjacent reticular formation (the nucleus reticularis supragigantocellularis). These labeled neurons are strikingly heterogeneous in size and morphology. The nuclei supragenualis and intercalatus also contain numerous labeled neurons in the 2 cases in which the injections involve the caudal SC. Large numbers of retrogradely labeled neurons as well as anterogradely transported WGA-HRP are observed alo throughout the pontine and medullary reticular formation, including the midline raphe. The PH complex, particularly the NPH, is known to be involved in the coding of eye position and has been hypothesized to be a critical component of the “neural integrator.” Our data demonstrate the existence of a robust projection from the PH complex to the contralateral SC in the rhesus monkey. This projection may serve as the anatomical substrate by which a corollary of eye position could reach the SC. Such a signal is a prerequisite for the computation, at the collicular level, of saccadic motor error signals observed in the SC of rhesus monkeys.

Keywords

Nucleus prepositus hypoglossiSuperior colliculusWheat germ agglutinin-horseradish peroxidaseSaccadic motor errorEye position signalNeural integrator
Type
Research Articles
Information
Visual Neuroscience , Volume 4 , Issue 1 , January 1990 , pp. 29 - 42
Copyright
Copyright © Cambridge University Press 1990

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