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Expansion of visual receptive fields in experimental glaucoma

Published online by Cambridge University Press:  09 March 2006

WAYNE MICHAEL KING ,
VIMAL SARUP ,
YVES SAUVÉ ,
COLLEEN M. MORELAND ,
DAVID O. CARPENTER  and
S.C. SHARMA
WAYNE MICHAEL KING
Affiliation:
Departments of Ophthalmology and Cell Biology & Anatomy, New York Medical College, Valhalla, New York Institute for Health and the Environment, University at Albany, Rensselaer, New York
VIMAL SARUP
Affiliation:
Departments of Ophthalmology and Cell Biology & Anatomy, New York Medical College, Valhalla, New York
YVES SAUVÉ
Affiliation:
Department of Ophthalmology, University of Alberta, Edmonton, Alberta, Canada
COLLEEN M. MORELAND
Affiliation:
Departments of Ophthalmology and Cell Biology & Anatomy, New York Medical College, Valhalla, New York
DAVID O. CARPENTER
Affiliation:
Institute for Health and the Environment, University at Albany, Rensselaer, New York
S.C. SHARMA
Affiliation:
Departments of Ophthalmology and Cell Biology & Anatomy, New York Medical College, Valhalla, New York
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Abstract

Glaucoma is a major cause of blindness and is characterized by death of retinal ganglion cells. In a rat model of glaucoma in which intraocular pressure is raised by cautery of episcleral veins, the somata and dendritic arbors of surviving retinal ganglion cells expand. To assess physiological consequences of this change, we have measured visual receptive-field size in a primary retinal target, the superior colliculus. Using multiunit recording, receptive-field sizes were measured for glaucomatous eyes and compared to both those measured for contralateral control eyes and to homolateral eyes of unoperated animals. Episcleral vein occlusion increased intraocular pressure. This was accompanied by a significant increase in receptive-field size across the superior colliculus. The expansion of receptive fields was proportional to both degree and duration of the increase of intraocular pressure. We suggest that this increase in the size of receptive fields of glaucomatous eyes may be related to the increase in the size of dendritic arbors of the surviving ganglion cells in retina.

Keywords

GlaucomaSuperior colliculusReceptive fieldRatElectrophysiology
Type
Research Article
Information
Visual Neuroscience , Volume 23 , Issue 1 , January 2006 , pp. 137 - 142
Copyright
2006 Cambridge University Press

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