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Dopamine synthesis and metabolism in rhesus monkey retina: Development, aging, and the effects of monocular visual deprivation

Published online by Cambridge University Press:  02 June 2009

P. Michael Iuvone ,
Margarete Tigges ,
Alcides Fernandes  and
Johannes Tigges
P. Michael Iuvone
Affiliation:
Department of Pharmacology, Emory University, Atlanta Department of Ophthalmology, Emory University, Atlanta Yerkes Regional Primate Research Center (YRPRC), Emory University, Atlanta
Margarete Tigges
Affiliation:
Department of Anatomy and Cell Biology, Emory University, Atlanta Department of Ophthalmology, Emory University, Atlanta Yerkes Regional Primate Research Center (YRPRC), Emory University, Atlanta
Alcides Fernandes
Affiliation:
Yerkes Regional Primate Research Center (YRPRC), Emory University, Atlanta
Johannes Tigges
Affiliation:
Department of Anatomy and Cell Biology, Emory University, Atlanta Department of Ophthalmology, Emory University, Atlanta Yerkes Regional Primate Research Center (YRPRC), Emory University, Atlanta
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Abstract

The normal postnatal development, the influence of age, and the effects of visual deprivation on the dopamine system in the retina of rhesus monkeys were examined. The lowest level of retinal dopamine was found at birth. By 3–4 weeks of age, the dopamine concentration had more than doubled. This level remained relatively constant in the retinas of older infants and of adult monkeys up to 34 yr of age. The level of the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) and the activity of tyrosine hydroxylase did not significantly change as a function of age during the postnatal life span.

Monocular occlusion of newborn or infant monkeys for 1–15 months with opaque contact lenses resulted in decreases in the retinal concentrations of dopamine and DOPAC relative to the concentrations in the same animals' unoccluded eyes. Occlusion also resulted in a lower level of tyrosine hydroxylase activity in the retina. Monocular eyelid suture from birth to 15 months of age resulted in less consistent alterations of retinal dopamine and DOPAC levels; tyrosine hydroxylase activity, however, was consistently reduced by lid suture. Thus, dopamine synthesis and metabolism, and the ontogenetic increase of the retinal dopamine level of rhesus monkey are reduced by light deprivation.

Keywords

RetinaDopamineDevelopmentAgingVisual deprivationRhesus monkey
Type
Research Article
Information
Visual Neuroscience , Volume 2 , Issue 5 , May 1989 , pp. 465 - 471
Copyright
Copyright © Cambridge University Press 1989

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