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The circadian component of spinule dynamics in teleost retinal horizontal cells is dependent on the dopaminergic system

Published online by Cambridge University Press:  02 June 2009

H.-J. Wagner ,
U. D. Behrens ,
M. Zaunreiter  and
R. H. Douglas
H.-J. Wagner
Affiliation:
Institut für Anatomie und Zellbiologie der Philipps Universität, Marburg, Germany
U. D. Behrens
Affiliation:
Institut für Anatomie und Zellbiologie der Philipps Universität, Marburg, Germany
M. Zaunreiter
Affiliation:
Institut für Anatomie und Zellbiologie der Philipps Universität, Marburg, Germany
R. H. Douglas
Affiliation:
Applied Vision Research Centre, Department of Optometry and Visual Science, City University, London, U.K.
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Abstract

During the light phase of a light/dark cycle, dendrites of teleost cone horizontal cells display numerous finger-like projections, called spinules, which are formed at dawn and degraded at dusk, and are thought to be involved in chromatic feedback processes. We have studied the oscillations of these spinules during a normal light/dark cycle and during 48 h of constant darkness in two groups of strongly rhythmic, diurnal fish, Aequidens pulcher. In one group the retinal dopaminergic system had been destroyed by the application of 6-OHDA, while in the other (control) group, the dopaminergic system was intact. In control fish, oscillations of spinule numbers were observed under both normal and constant dark conditions, indicating the presence of a robust circadian rhythm. However, spinule dynamics were severely affected by the absence of retinal dopamine. During the normal light phase, the number of spinules in 6-OHDA injected retinae was strongly reduced, and throughout continual darkness, spinule formation was almost completely suppressed. These results indicate that dopamine is essential for both light-evoked and circadian spinule formation; furthermore, we conclude that there is no circadian oscillator within horizontal cells controlling the formation of spinules.

Keywords

AdaptationDopamine6-HydroxydopamineEndogenous circadian rhythmSynaptic plasticity
Type
Research Articles
Information
Visual Neuroscience , Volume 9 , Issue 3-4 , October 1992 , pp. 345 - 351
Copyright
Copyright © Cambridge University Press 1992

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