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The cellular basis for suppressive rod–cone interaction

Published online by Cambridge University Press:  02 June 2009

Thomas E. Frumkes  and
Thor Eysteinsson
Thomas E. Frumkes
Affiliation:
Department of Psychology, Queens College of CUNY, Flushing
Thor Eysteinsson
Affiliation:
Department of Psychology, Queens College of CUNY, Flushing
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Abstract

The response to spatially focal flicker is enhanced by dim, spatially diffuse, rod-stimulating backgrounds. This effect is called suppressive rod-cone interaction (SRCI) as it reflects a tonic, suppressive influence of dark-adapted rods upon cone pathways which is removed by selective rod-light adaptation. SRCI is observed in amphibian retina with intracellular recordings from most cone-driven cells including the cones themselves, and is most obvious using stimuli flickering at frequencies too rapid for rods to follow. SRCI is blocked by glutamate analogs which selectively block the photic response of horizontal cells (HCs). In the presence of these agents, flicker responses from bipolar cells and cones are enhanced to levels normally seen only with selective rod-light adaptation. In the HCs themselves, SRCI is similarly blocked by lead chloride which blocks rod-, but not cone-related activity.

In amphibian and cat HCs and in human observers, SRCI is limited by a space constant of very similar value (between 100 and 150 μm). We suggest that SRCI in all three species is mediated by HCs: in amphibians, SRCI must at least partially reflect rod-modulation of HC feedback onto cones.

Keywords

ConesRodsBipolar cellsHorizontal cellsFlicker responses
Type
Research Article
Information
Visual Neuroscience , Volume 1 , Issue 3 , May 1988 , pp. 263 - 273
Copyright
Copyright © Cambridge University Press 1988

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