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Bistratified distribution of terminal arbors of individual axons projecting from area V1 to middle temporal area (MT) in the macaque monkey

Published online by Cambridge University Press:  02 June 2009

Kathleen S. Rockland
Kathleen S. Rockland
Affiliation:
Eye Research Institute and Department of Anatomy, Boston University School of Medicine, Boston
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Abstract

In the present study, the anterograde tracer Phaseolus vulgaris-leucoagglutinin was injected into area V1 in order to demonstrate the detailed morphology of individual axons terminating in prestriate area MT. On the basis of 24 axon reconstructions, several representative (but not necessarily comprehensive) characteristics have been identified: (1) Most axons arborize in a patchy manner over a widespread territory, frequently greater than 1.0 mm and often up to 1.5 × 1.8 mm (dimensions uncorrected for shrinkage). (2) Terminal arbors are distributed to layers 3, 4, and 6. Those in layer 6 need not be in register with those in the upper layers. (3) Number and size of terminal arbors are variable. One axon may have 1–4 arbors in the middle layers; typically at least one of these will have a diameter of 200–250 µm, while the others may be less developed. There are from 1–3 arbors in layer 6, usually 50 µm (but sometimes up to 100 µm) in diameter. (4) Terminal boutons are of mixed morphology, but usually beaded and large (up to 3.0 µm). (5) In the white matter, many axons travel in the external sagittal stratum but some are part of the U-fiber system. Axons commonly branch, sometimes at depths up to 0.75–1.0 mm, below the gray matter of MT. In summary, these axons are not stereotyped, but rather vary in the number and size of their terminal arbors, as well as in their branching and overall geometry.

Connections from area V1 to MT have been associated with the magnocellular-dominated “processing channel.” As widespread arborizations and bistratified terminations are common to both striate axons in MT and to geniculocortical axons in layer 4Cα of primary visual cortex, these features might be correlated with magnocellular-specific processing requirements.

Keywords

Axon terminal distributionCortico-cortical afferentsModular organizationPHA-LVisual cortex
Type
Research Articles
Information
Visual Neuroscience , Volume 3 , Issue 2 , August 1989 , pp. 155 - 170
Copyright
Copyright © Cambridge University Press 1989

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