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Otitis Media: Genetic Factors and Sex Differences

Published online by Cambridge University Press:  21 February 2012

Ellen Kvestad ,
Kari J. Kværner ,
Espen Røysamb ,
Kristian Tambs ,
Jennifer R. Harris  and
Per Magnus
Ellen Kvestad*
Affiliation:
Division of Epidemiology,The Norwegian Institute of Public Health, Oslo, [email protected]
Kari J. Kværner
Affiliation:
Center for Health Administration, the National Hospital, University of Oslo, Norway
Espen Røysamb
Affiliation:
Division of Epidemiology,The Norwegian Institute of Public Health, Oslo, Norway
Kristian Tambs
Affiliation:
Division of Epidemiology,The Norwegian Institute of Public Health, Oslo, Norway
Jennifer R. Harris
Affiliation:
Division of Epidemiology,The Norwegian Institute of Public Health, Oslo, Norway
Per Magnus
Affiliation:
Division of Epidemiology,The Norwegian Institute of Public Health, Oslo, Norway
*
*Address for correspondence: Ellen Kvestad, Division of Epidemiology, The Norwegian Institute of Public Health, Pb 4404 Nydalen, N – 0403 Oslo, Norway.

Abstract

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Although genetic factors are recognised as major contributors to otitis media, the presence of sex differences in heritability needs clarification. The aim of this study was to estimate the relative contribution of genetic and environmental effects in otitis media liability with particular focus on sex differences. Data from a cohort of Norwegian twins born between 1967 and 1979 with repeated measures on recurrent childhood otitis media were analysed. Altogether the sample included 4247 twin pairs. The tetrachoric correlations for monozygotic twins were .71 and .65 for males and females respectively. In dizygotic twins the correlations were .35 and .25 for males and females, respectively, and was .34 in opposite sexed pairs. The contribution of genetic and environmental effects was analyzed using structural equation modeling. The best fitting model showed that additive genetic effects explained 72% and 61% of the variance in males and females, respectively. The remaining variance was attributed to individual environmental effects. A model specifying equal heritability estimates for males and females yielded an almost equivalent fit. We found substantial genetic effects for liability to otitis media. There is no evidence that different sets of genes influence liability in males and females, but there may be sex differences in the relative importance of genetic effects.

Type
Articles
Information
Twin Research and Human Genetics , Volume 7 , Issue 3 , 01 June 2004 , pp. 239 - 244
Copyright
Copyright © Cambridge University Press 2004