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No Linkage to Obesity in Candidate Regions of Chromosome 2 and 10 in a Selected Sample of Swedish Twins

Published online by Cambridge University Press:  21 February 2012

Anastasia Iliadou ,
Paul Lichtenstein ,
Susanne Ahlberg ,
Johan Hoffstedt ,
Peter Arner ,
Martin Schalling ,
Nancy L. Pedersen  and
Catharina Lavebratt
Anastasia Iliadou*
Affiliation:
Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden. [email protected]
Paul Lichtenstein
Affiliation:
Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden.
Susanne Ahlberg
Affiliation:
Center for Molecular Medicine, Karolinska Institutet, Karolinska Hopsital, Stockholm, Sweden.
Johan Hoffstedt
Affiliation:
Department of Medicine, Karolinska Institutet, Huddinge Hospital, Huddinge, Sweden.
Peter Arner
Affiliation:
Department of Medicine, Karolinska Institutet, Huddinge Hospital, Huddinge, Sweden.
Martin Schalling
Affiliation:
Center for Molecular Medicine, Karolinska Institutet, Karolinska Hopsital, Stockholm, Sweden.
Nancy L. Pedersen
Affiliation:
Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden.
Catharina Lavebratt
Affiliation:
Center for Molecular Medicine, Karolinska Institutet, Karolinska Hopsital, Stockholm, Sweden.
*
*Address for correspondence: Anastasia Iliadou, Department of Medical Epidemiology, Karolinska Institutet, Box 281, 171 77 Stockholm, Sweden.

Abstract

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The aim of the current study was to investigate the importance of genetic and environmental effects in the variation of body mass index, and to investigate linkage for obesity to previously reported candidate regions on chromosome 2 and 10. A sample of 1422 twin pairs from the population based Swedish Twin Registry was used in order to estimate the genetic and environmental effects in the variation of body mass index by means of structural equation modeling. A selection of those, 51 concordant and 155 discordant for obesity, was used for the linkage analysis by implementing the “combined” Haseman-Elston approach. Heritability of body mass index ranged from 59–70%, implying that genetic effects were of importance for the variation of obesity, and there were significant sex and age differences. Linkage could not be verified in candidate regions of chromosomes 2 and 10, indicating that these genetic variants have a significant effect in extreme obese populations rather than in moderately obese Caucasians. However, the results were sensitive to issues related to power, minor effects of the genes, ethnic differences and the complex mechanism underlying obesity.

Type
Articles
Information
Twin Research and Human Genetics , Volume 6 , Issue 2 , 01 April 2003 , pp. 162 - 169
Copyright
Copyright © Cambridge University Press 2003