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Familial Monozygotic Twinning: Report of an Extended Multi-generation Family

Published online by Cambridge University Press:  21 February 2012

Hanan A. Hamamy ,
Heitham K. Ajlouni  and
Kamel M. Ajlouni
Hanan A. Hamamy
Affiliation:
National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan
Heitham K. Ajlouni
Affiliation:
National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan
Kamel M. Ajlouni*
Affiliation:
National Center for Diabetes, Endocrinology and Genetics, Amman, [email protected]
*
*Address for correspondence: Professor Kamel Ajlouni, Head of National Center for Diabetes, Endocrinology and Genetics, P.O. Box 13165, Amman, Jordan.

Abstract

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Thirteen sets of monozygotic (MZ) twins from an extended multi-generation family are reported. Zygosity was determined by interviewing families for overall physical similarity and by assessment of facial photographs. A hypothetical gene was traced back five generations to a common grandfather. Familial monozygotic twinning in this pedigree is compatible with autosomal dominant inheritance with reduced penetrance. Other plausible mechanisms of inheritance are discussed.

Type
Articles
Information
Twin Research and Human Genetics , Volume 7 , Issue 3 , 01 June 2004 , pp. 219 - 222
Copyright
Copyright © Cambridge University Press 2004