In this article and the following one, Susan Blackmore and Michael Bradie take contrary positions on the ‘science of memetics’, an approach to explaining human behaviour and culture based on the idea that our minds and cultures are in large part determined by self-replicating gene-like entities called ‘memes’. Memes would seem to allow the application of evolutionary ideas to both biology and culture. Many find that thought exciting and appealing. Others consider it arrogant and scientistic. Who is right?