From the viewpoint of hard tissue response to implant materials, calcium phosphates are probably the most compatible materials presently known. During the last few years, much attention has been paid to hydroxyapatite and β-tricalcium phosphate as potential biomaterials for bonesubstitute. A good implantation of biomaterials in the skeleton is to reach fullintegration of non-living implant with living bone. The aim of this study is tocompare the resorption kinetics of four kinds of calcium phosphate ceramics:hydroxyapatite (Ca10(PO4)6(OH)2), hydroxyapatite doped with manganese orzinc and a composite material of 75% hydroxyapatite and 25% β-tricalciumphosphate (Ca3(PO4)2). Cylinders (5–6 mm in diameter) of these ceramics werepacked into holes made in the femur diaphysis of mature ovine.At 2, 4, 8, 12, 16, 20, 28, 36 and 48 weeks after the operation, bone/implant interfacewas embedded in polymethylmethacrylate. We used the PIXE method (particle inducedX-ray emission) to measure the distribution of mineral elements (Ca, P, Sr, Zn, Mn andFe) at the bone/implant interface. At 4, 8, 16, 28 and 48 weeks after implantation westudied a biopsy of the ceramics by neutron activation method. Then, we have a globalmeasurement of mineral elements in the biomaterial. The results showed that theresorption kinetics of hydroxyapatite doped with zinc was faster than that of the three other bioceramics.