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The effect of coating of Fe3O4/silica core/shell nanoparticles on T2 relaxation time at 9.4 T

Published online by Cambridge University Press:  21 July 2011

B. Blasiak ,
Z. Zhang ,
X. Zhang ,
T. Foniok ,
G. R. Sutherland ,
T. Veres  and
B. Tomanek
B. Blasiak*
Affiliation:
Department of Clinical Neurosciences, University of Calgary, 1403 – 29th Street NW, Calgary, T2N 4N1, Alberta, Canada Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Krakow, Malopolska, Poland Institute for Biodiagnostics (West), National Research Council of Canada, 3330 Hospital Dr. NW Calgary, T2N 4N1, Alberta, Canada
Z. Zhang
Affiliation:
Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, 398 Ruoshui Rd, Duhu Lake Higher Education District, Suzhou Industrial Park, Suzhou, 215125, P.R. China
X. Zhang
Affiliation:
Industrial Material Institute, National Research Council of Canada, 75 de Mortagne Boulevard, Boucherville, J4B 6Y4, Québec, Canada
T. Foniok
Affiliation:
Institute for Biodiagnostics (West), National Research Council of Canada, 3330 Hospital Dr. NW Calgary, T2N 4N1, Alberta, Canada
G. R. Sutherland
Affiliation:
Department of Clinical Neurosciences, University of Calgary, 1403 – 29th Street NW, Calgary, T2N 4N1, Alberta, Canada
T. Veres
Affiliation:
Industrial Material Institute, National Research Council of Canada, 75 de Mortagne Boulevard, Boucherville, J4B 6Y4, Québec, Canada Énergie, Matériaux et Télécommunications, Institut national de la recherche scientifique, Université du Québec, 1650 boulevard Lionel-Boulet, Varnennes, J3X 1S2, Québec, Canada
B. Tomanek*
Affiliation:
Department of Clinical Neurosciences, University of Calgary, 1403 – 29th Street NW, Calgary, T2N 4N1, Alberta, Canada Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342 Krakow, Malopolska, Poland Institute for Biodiagnostics (West), National Research Council of Canada, 3330 Hospital Dr. NW Calgary, T2N 4N1, Alberta, Canada
*
ae-mail: [email protected]
ae-mail: [email protected]
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Abstract

Magnetic Resonance Imaging (MRI) that provides superior soft tissue contrast is commonly used for diagnosis of many diseases. However specificity of MRI cancer diagnosis can be further increased by application of target contrast agents comprising superparamagnetic nanoparticles (NPs) synthesised with biological objects, which deliver the contrast to the specific cancer cells. These superparamagnetic NPs shorten T2 relaxation time thus change contrast to noise ratio for tumor tissues. Therefore the impact of Fe3O4 size and silica coating for Fe3O4/silica core/shell superparamagnetic nanoparticles (NPs) on T2 relaxation time was studied at 9.4 T. The magnetic resonance imaging (MRI) studies were performed using homogenous agar solution of NPs. Naked Fe3O4NPs with a mean core diameter of 10.0 ± 1.3 (mean ± SD), 15.0 ± 2.5 and 20.0 ± 0.9 nm were analyzed. Silica coated Fe3O4 NPs with core size of 10.0 ± 1.3 nm and the shell thickness of 16.7 ± 1.8, 25.3 ± 2.7 and 33.9 ± 4.0 nm were also investigated. The T2 values of agar solutions with different NPs were calculated using a single slice multi echo method and single exponential fitting of the echo train. The measurements showed linear correlation between T2 and Fe3O4 core diameter as well as shell thickness. Silica coating, while improving functionalization and potentially reducing toxicity of NPs, decreases the impact of the magnetic core on T2, thus decreasing MRI contrast efficacy.

Type
Research Article
Information
The European Physical Journal - Applied Physics , Volume 55 , Issue 1: Focus on Hakone XII , July 2011 , 10401
Copyright
© EDP Sciences, 2011

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