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Viral mutation and its influence in the time evolutionof the immunizations

Published online by Cambridge University Press:  12 June 2009

A. de Castro  and
D. Alves
A. de Castro*
Affiliation:
Embrapa Informática Agropecuária, Empresa Brasileira de Pesquisa Agropecuária, EMBRAPA, Caixa Postal 6041, 13083-886 Campinas, Brazil Departamento de Informática em Saúde, Universidade Federal de São Paulo, UNIFESP, Brazil
D. Alves
Affiliation:
Departamento de Informática em Saúde, Universidade Federal de São Paulo, UNIFESP, Brazil Departamento de Medicina Social, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, USP, Brazil
*
[email protected]
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Abstract

In this paper, we study the behavior of immune memory against antigenic mutation. Using a dynamic model proposed by one of the authors in a previous study (A. de Castro [Phys. J. Appl. Phys. 33, 147 (2006) and Simul. Mod. Pract. Theory. 15, 831 (2007)]), we have performed simulations of several inoculations, where in each virtual sample the viral population undergoes mutations. Our results suggest that the sustainability of the immunizations is dependent on viral variability and that the memory lifetimes are not random, what contradicts what was suggested by Tarlinton et al. [Curr. Opin. Immunol. 20, 162 (2008)]. We show that what may cause an apparent random behavior of the immune memory is the antigenic variability.

Keywords

Type
Research Article
Information
The European Physical Journal - Applied Physics , Volume 47 , Issue 3 , September 2009 , 31401
Copyright
© EDP Sciences, 2009

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