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Transformation threshold and time-dependent TAF generation in an angiogenesis model

Published online by Cambridge University Press:  02 December 2003

B. Capogrosso Sansone ,
C. A. Condat  and
M. Scalerandi
B. Capogrosso Sansone
Affiliation:
INFM, Dipartimento di Fisica, Politecnico di Torino, Torino, Italy Los Alamos National Laboratory, Los Alamos, New Mexico, USA
C. A. Condat*
Affiliation:
CONICET and FaMAF, Universidad Nacional de Córdoba, 5000 – Córdoba, Argentina Department of Physics, University of Puerto Rico, Mayaguez, PR 00681, USA
M. Scalerandi
Affiliation:
INFM, Dipartimento di Fisica, Politecnico di Torino, Torino, Italy
*
[email protected][email protected]
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Abstract

Angiogenesis ensures the success of cancer growth. This enlargement of the vascular system feeding a tumor is induced by tumor angiogenic factors (TAFs), which are molecular messengers emitted by starving cancer cells. We apply a recently developed angiogenesis model to study the influence of variations in the TAF generation rate on vascular growth and to analyze the effects of changing the threshold for endothelial cell transformation, which is a crucial parameter in the description of this process.

Keywords

Type
Research Article
Information
The European Physical Journal - Applied Physics , Volume 25 , Issue 2 , February 2004 , pp. 133 - 140
Copyright
© EDP Sciences, 2004

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