Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-25T18:14:10.809Z Has data issue: false hasContentIssue false
  • English
  • Français

Multi-element synthetic aperture focusing photoacoustic imaging system with real-time digital beamformer technique

Published online by Cambridge University Press:  30 November 2010

X. Ji  and
S. Yang
X. Ji
Affiliation:
MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, P.R. China
S. Yang*
Affiliation:
MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, P.R. China
*
[email protected]
Get access

Abstract

Photoacoustic imaging takes the merits of simultaneous high optical contrast and low acoustical scattering, and has been proven to be a potential tool for noninvasive diagnosis of cancer tumors in an early stage. An integrated prototype multi-element synthetic aperture focusing photoacoustic imaging system using real-time digital beamformer (96 scan lines of each frame image) is designed, fabricated and tested. The combined system with multi-channel signal acquisition and real-time digital beam-formation module implements real-time dynamic receiving focus and apodization technique to process the photoacoustic signal, which is captured by a 128-element linear ultrasonic transducer array. The data acquisition and synthesis time can be accelerated in less than 4 s of each view without data average. The in vivo experiments were performed with a clear view of the blood vessels network of mouse tumor. The results demonstrate that the multi-element synthetic aperture focusing photoacoustic imaging system with real-time digital beamformer technique has the potential in the practical fast photoacoustic imaging for clinical diagnosis.

Type
Research Article
Information
The European Physical Journal - Applied Physics , Volume 52 , Issue 3 , December 2010 , 30901
Copyright
© EDP Sciences, 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Wang, Y., Xing, D., Zeng, Y., Chen, Q., Phys. Med. Biol. 49, 3117 (2004) CrossRef
Zeng, Y., Xing, D., Wang, Y., Yin, B., Chen, Q., Opt. Lett. 2, 1760 (2004) CrossRef
Nie, L., Xing, D., Yang, D., Zeng, L., Zhou, Q., Appl. Phys. Lett. 90, 174109 (2007) CrossRef
Nie, L., Xing, D., Zhou, Q., Yang, D., Guo, H., Med. Phys. 35, 4026 (2008) CrossRef
Kolkman, R.G.M., Klaessens, J.H.G.M., Hondebrink, E., Hopman, J.C.W., de Mul, F.F.M., Steenbergen, W., Thijssen, J.M., van Leeuwen, T.G., Phys. Med. Biol. 49, 4745 (2004) CrossRef
Zeng, L., Xing, D., Gu, H., Yang, D., Yang, S., Xiang, L., Med. Phys. 34, 556 (2007) CrossRef
Su, Y., Zhang, F., Xu, K., Yao, J., Wang, R.K., J. Phys. D: Appl. Phys. 38, 2640 (2005) CrossRef
Heng, Y., Tang, Z., Chen, Z., Wan, W., Li, J., Phys. Med. Biol. 51, 2671 (2006)
Yang, D., Xing, D., Gu, H., Tan, Y., Zeng, L., Appl. Phys. Lett. 87, 194101 (2005) CrossRef
Oraevsky, A.A., Andreev, V.A., Karabutov, A.A., Fleming, D.R., Gatalica, Z., Singh, H., Esennaliev, R.O., Proc. SPIE 3597, 352 (1999) CrossRef
Yang, D., Xing, D., Yang, S., Xiang, L., Opt. Express 15, 15566 (2007) CrossRef
Wang, X., Pang, Y., Ku, G., Xie, X., Stoica, G., Wang, L.V., Nat. Biotechnol. 21, 803 (2003) CrossRef
Yang, S., Xing, D., Lao, Y., Yang, D., Zeng, L., Xiang, L., Chen, W., Appl. Phys. Lett. 90, 243902 (2007) CrossRef
Yang, S., Gu, H., Eur. Phys. J. Appl. Phys. 37, 87 (2007) CrossRef
Hoelen, C.G.A., de Mul, F.F.M., Appl. Opt. 39, 5872 (2000) CrossRef
Yang, S., Xing, D., Zhou, Q., Xiang, L., Lao, Y., Med. Phys. 34, 3294 (2007) CrossRef
Lao, Y., Zhou, F., Wang, H., Eur. Phys. J. Appl. Phys. 41, 151 (2008) CrossRef
Yin, B., Xing, D., Wang, Y., Zeng, Y., Tan, Y., Chen, Q., Phys. Med. Biol. 49, 1339 (2004) CrossRef
Niederhauser, J.J., Jaeger, M., Lemor, R., Weter, P., Frenz, M., IEEE Trans. Med. Imaging 24, 436 (2005) CrossRefPubMed
Wang, H., Xing, D., Xiang, L., J. Phys. D: Appl. Phys. 41, 095111 (2008) CrossRef
Kruger, R.A., Kiser Jr, W.L.., D.R. Reinecke, G.A. Kruger, Med. Phys. 30, 856 (2003) CrossRef
Ermilov, S.A., Conjusteau, A., Mehta, K., Lacewell, R., Henrichs, P.M., Oraevsky, A.A., Proc. SPIE 6086, 608609 (2006) CrossRef
Li, M., Guan, W., Li, P., IEEE Trans. Ultrason. Ferroelectron. Freq. Control 51, 63 (2004) CrossRef
Xu, M., Ku, G., Wang, L.V., Med. Phys. 28, 1958 (2001) CrossRef