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Within-Individual Variation in Steady State Plasma Levels of Different Neuroleptics and Prolactin

Published online by Cambridge University Press:  29 January 2018

R. G. McCreadie ,
Margaret Mackie ,
David H. Wiles ,
Aksel Jorgensen ,
Villy Hansen  and
Colin Menzies
R. G. McCreadie
Affiliation:
Crichton Royal Hospital, Dumfries DG1 4TG
Margaret Mackie
Affiliation:
Dumfries and Galloway Royal Infirmary, Dumfries DG1 4AP
David H. Wiles
Affiliation:
Crichton Royal Hospital, Dumfries DG1 4TG
Aksel Jorgensen
Affiliation:
Department of Biochemistry, Lundbeck Limited, Copenhagen
Villy Hansen
Affiliation:
Department of Data Processing, Lundbeck Limited, Copenhagen
Colin Menzies
Affiliation:
Crichton Royal Hospital, Dumfries DG1 4TG
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Summary

Eleven male chronic schizophrenics were given, serially, oral pimozide, fluphenazine, and flupenthixol; the two latter were also given intramuscularly as decanoates in oil. Oral haloperidol was given before and after each drug. Analysis of variance of steady state plasma levels of the different neuroleptics showed considerable within-individual variation in such levels, probably due to differences in absorption and metabolism and between routes of administration. The findings suggest that if a patient fails to respond to one neuroleptic, there may be good pharmacokinetic reasons for switching him to another belonging to a different group, or for giving the same neuroleptic by a different route of administration. The study also showed that previous administration of one neurololeptic may influence the steady state level of another. The various neuroleptics produced different effects on plasma prolactin levels.

Type
Papers
Information
The British Journal of Psychiatry , Volume 144 , Issue 6 , June 1984 , pp. 625 - 629
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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