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Withdrawal Symptoms from Lithium

Four Case Reports and a Questionnaire Study

Published online by Cambridge University Press:  29 January 2018

J. R. King  and
R. P. Hullin
J. R. King
Affiliation:
Departments of Biochemistry and Psychiatry, University of Leeds, 15 Hyde Terrace, Leeds LS2 9LT
R. P. Hullin
Affiliation:
University of Leeds; Regional Metabolic Research Unit, High Royds Hospital, nr. Ilkley, West Yorkshire
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Summary

Evidence from four case reports of heightened anxiety, irritability and emotional lability following withdrawal of lithium was confirmed by a questionnaire survey of 110 defaulters from a lithium clinic: 19 per cent of respondents retrospectively reported these temporary symptoms following withdrawal. The possible mechanisms of such a withdrawal effect are discussed, and a phased withdrawal is advocated in situations where continued clinical benefit from lithium is being evaluated. The questionnaire results also confirm anecdotal evidence that lithium reduces emotional responsiveness. The significance of these findings in terms of the current models of lithium's action is discussed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 143 , Issue 1 , July 1983 , pp. 30 - 35
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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References

Baastrup, P. C. & Schou, M. (1967) Lithium as a prophylactic agent. Archives of General Psychiatry, 16, 162–72.Google Scholar
Gold, P. W. & Goodwin, F. K. (1978) Vasopressin in affective illness. Lancet, i, 1233–5.Google Scholar
Johnson, F. N. (1979) The psychopharmacology of lithium. Neuroscience and Biobehavioral Reviews, 3, 26.Google Scholar
Judd, L. L. (1979) Effect of lithium on mood, cognitive and personality function in normal subjects. Archives of General Psychiatry, 36, 860–5.Google Scholar
Klein, H. E., Broucek, B. & Greil, W. (1981) Lithium withdrawal triggers psychotic states. British Journal of Psychiatry, 139, 255–6.Google Scholar
Lapierre, Y. D., Gagnon, A. & Kokkinidis, L. (1980) Rapid recurrence of mania following lithium withdrawal. Biological Psychiatry, 15, 859–64.Google Scholar
Margo, A. & McMahon, P. (1982) Lithium withdrawal triggers psychosis. British Journal of Psychiatry, 141, 407–10.Google Scholar
Müller-Oerlinghausen, B., Bauer, H., Girke, W., Kanowski, S. & Goncalves, N. (1977) Impairment of vigilance and performance under lithium treatment: studies in patients and normal volunteers. Pharmakopsychiatrie Neuro-psychopharmakologie, 10, 67–8.Google Scholar
Müller-Oerlinghausen, B., Hamann, S., Hermann, W. M. & Kropf, D. (1979) Effects of lithium on vigilance, psychomotive performance and mood. Pharmakopsychiatrie Neuro-psychopharmakologie, 12, 388–96.CrossRefGoogle Scholar
Rifkin, A., Quitkin, F., Howard, A. & Klein, D. (1975) A study of abrupt lithium withdrawal. Psychopharmacologia (Berl.), 44, 157–8.Google Scholar
Schou, M. J. (1967) Lithium in psychiatric therapy and prophylaxis. Journal of Psychiatric Research, 6, 67–95.Google Scholar
Schou, M. J. (1980) in Handbook of Lithium Therapy (ed. Johnson, F. N.). Lancaster: MTP Press.Google Scholar
Wilkinson, D. G. (1979) Difficulty in stopping lithium prophylaxis? British Medical Journal, 1, 235–6.Google Scholar
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