Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-22T08:38:23.495Z Has data issue: false hasContentIssue false

The Viral Theory of Schizophrenia

Published online by Cambridge University Press:  02 January 2018

T. J. Crow*
Affiliation:
Division of Psychiatry Clinical Research Centre Northwick Park Hospital Harrow, London HA1 3UJ
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Correspondence
Copyright
Copyright © Royal College of Psychiatrists, 1988 

References

Baker, H. F., Ridley, R. M. & Crow, T. J. (1985) Experimental transmission of an autosomal dominant spongiform encephalopathy: does the infectious agent originate in the human genome? British Medical Journal, 291, 299302.CrossRefGoogle ScholarPubMed
Crow, T. J. (1983) Is schizophrenia an infectious disease? The Lancet, i, 173175.CrossRefGoogle Scholar
Crow, T. J. (1984) A re-evaluation of the viral hypothesis: is psychosis the result of retroviral integration at a site close to the cerebral dominance gene? British Journal of Psychiatry, 145, 243253.CrossRefGoogle Scholar
Crow, T. J. (1986a) Left brain, retrotransposons and schizophrenia. British Medical Journal, 292, 34.CrossRefGoogle Scholar
Crow, T. J. (1986b) The continuum of psychosis and its implication for the structure of the gene. British Journal of Psychiatry, 149, 419429.CrossRefGoogle ScholarPubMed
Crow, T. J. (1987a) Integrated viral genes as potential pathogens in the functional psychoses. Journal of Psychiatric Research, 21, 479485.CrossRefGoogle ScholarPubMed
Crow, T. J. (1987b) Psychosis as a continuum and the virogene concept. British Medical Bulletin, 43, 754767.CrossRefGoogle ScholarPubMed
Crow, T. J. (1987c) Mutation and psychosis: a suggested explanation of seasonality of birth. Psychological Medicine, 17, 821828.CrossRefGoogle ScholarPubMed
Crow, T. J. (1987d) A pseudoautosomal locus for psychosis? The Lancet, ii, 1532.CrossRefGoogle Scholar
Crow, T. J. Colter, N., Brown, R., Bruton, C. J. & Johnstone, E. C. (1988a) Schizophrenia as an anomaly of the cerebral dominance gene, (in press).Google Scholar
Crow, T. J., DeLisi, L. E., Johnstone, E. C. (1988b) Concordance by sex! for psychosis is paternally inherited: evidence for a pseudoautosomal locus, (in press).Google Scholar
Crow, T. J. & Done, D. J. (1986) Age of onset of schizophrenia in siblings: a test of the contagion hypothesis. Psychiatric Research, 18, 107117.CrossRefGoogle ScholarPubMed
Holliday, R. (1987) The inheritance of epigenetic defects. Science, 238, 163170.CrossRefGoogle ScholarPubMed
jenkins, N. A. & Copeland, N. G. (1985) High frequency germ-line acquisition of ecotropic MuLV proviruses in SWR/J–RF/J hybrid mice. Cell, 43, 811819.CrossRefGoogle Scholar
Katzir, N., Rechavi, G., Cohen, J. B., Unger, T., Simoni, F., Segul, S., Cohen, D. & Givol, D. (1985) “Retroposon” insertion into the cellular oncogene c-myc in canine transmissible venereal tumor. Proceedings of the National Academy of Sciences, 82, 10541058.CrossRefGoogle ScholarPubMed
Kazazian, H. H., Wong, C., Youssoufian, H., Scott, A. F., Phillips, D. G. & Antonarakis, S. E. (1988) Haemophilia A resulting from de novo insertion of LI sequences represents a novel mechanism for mutation in man. Nature, 332, 164166.CrossRefGoogle Scholar
Kuff, E. L., Feenstra, A., Lueders, K., Smith, L., Hawley, R., Hozumi, N. & Shulman, M. (1983) Intracisternal A-particle genes as movable elements in the mouse genome. Proceedings of the National Academy of Sciences, 80, 19921996.CrossRefGoogle ScholarPubMed
Loeb, D. D., Padgett, R. W., Hardies, S. C., Shehee, W. R., Comer, M. B., Edgell, M. H. & Hutchison, C. A. (1986) The sequence of a large L1Md element reveals a tandemly repeated 5′ end and several features found in retrotransposons. Molecular Cell Biology, 6, 168182.Google ScholarPubMed
Murphy, W. H., Nawrocki, J. F., & Pease, L. R. (1983) Age-dependent paralytic viral infection in C58 mice: possible implications for human neurologic disease. Progress in Brain Research, 59, 291303.CrossRefGoogle ScholarPubMed
Ono, M., Kawakami, M. & Takezawa, T. (1987) A novel human nonviral retroposon derived from an endogenous virus. Nucleic Acids Research, 15, 87258737.CrossRefGoogle Scholar
Owen, F., Poulter, M., Lofthouse, R., Crow, T. J., Risby, D., Baker, H. F. & Ridley, R. M. (1988) A rare MSP1 polymorphism in the human prion gene in a family with a history of early onset dementia. Neuroscience Letters, Suppl. 32, S53.Google Scholar
Paulson, K. E., Doka, N., Schmid, G. W., Misra, R., Schindler, C. W., Rush, M. G., Kadyk, L. & Leinwand, L. (1985) A transposon-like element in human DNA. Nature, 316, 359361.CrossRefGoogle ScholarPubMed
Teich, N. (1982) Endogenous viruses In RNA Tumour Viruses (2nd edn) (eds Weiss, R., Teich, N., Varmus, H. & Coffin, J.) pp 11091203. New York: Cold Spring Harbor Laboratory.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.