Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-25T09:06:49.867Z Has data issue: false hasContentIssue false
  • English
  • Français

Viloxazine in the Treatment of Depressive Neurosis: A Controlled Clinical Study with Doxepin and Placebo

Published online by Cambridge University Press:  29 January 2018

Joseph P. McEvoy ,
William F. Sheridan ,
W. R. C. Stewart Jr. ,
Thomas A. Ban ,
William H. Wilson ,
William Guy  and
J. David Schaffer
Joseph P. McEvoy
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
William F. Sheridan
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
W. R. C. Stewart Jr.
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
Thomas A. Ban
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
William H. Wilson
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
William Guy
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
J. David Schaffer
Affiliation:
Tennessee Neuropsychiatric Institute, Clinical Research Service, 1501 Murfreesboro Road, Nashville, Tennessee 37217, U.S.A.
Get access Rights & Permissions [Opens in a new window]

Summary

In a four-week, double-blind, clinical trial thirty-one patients with depressive neurosis were treated with viloxazine, doxepin, or placebo. There were no differences among the three groups in therapeutic effects. Many depressed out-patients improve on placebo. Viloxazine hydrochloride is one of a series of compounds developed to explore the central nervous system activity of the aryloxypropanolamine type of β-adreno-receptor antagonists. Initial clinical studies support the hypothesis that viloxazine has antidepressant properties in man (Bayliss et al, 1974; Bereen, 1973; Pichot et al, 1975; Tsegos and Ekdawi, 1974).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 5 , November 1980 , pp. 440 - 443
Copyright
Copyright © Royal College of Psychiatrists, 1980 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Amsterdam, J., Brunswick, D. & Mendels, J. (1980) The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels. American Journal of Psychiatry, 137, 653–62.Google ScholarPubMed
Bayliss, P. F. C., Dewsbury, A. R., Donald, J. F., Harcup, J. W., Mayer, M., Million, R., Molla, A. L., Murphy, J. E., Plant, B. & Shaoul, E. (1974) A double-blind controlled trial of ‘vivalan’ (viloxazine hydrochloride) and imipramine hydrochloride in the treatment of depression in general practice. Journal of International Medical Research, 2 (4), 260–4.Google Scholar
Bereen, F. J. (1973) A new potential antidepressive. Lancet, i, 379–80.Google Scholar
Kiloh, L. G. & Garside, R. F. (1963) The independence of neurotic depression and endogenous depression. British Journal of Psychiatry, 109, 451–63.Google Scholar
Lasagna, L. (1971) Decision processes in establishing the efficacy and safety of psychoactive agents. In Principles and Problems in Establishing the Efficacy of Psychotropic Agents (eds. J. Levine, B. C. Schiele, and L. Bouthilet). Public Health Service Publication No. 2138.Google Scholar
Overall, J. E., Hollister, L. E., Pokorny, A. D., Casey, J. F. & Katz, G. (1962) Drug therapy in depressions. Controlled evaluation of imipramine, isocarboxazid, dextroamphetamine, amobarbital, and placebo. Clinical Pharmacology and Therapeutics, 3, 16.Google Scholar
Pichot, P., Guelfi, J. & Dreyfus, J. F. (1975) A controlled multicentre therapeutic trial of viloxazine (vivalan). Journal of International Medical Research, 3, Suppl 3, 80–6, 100.Google Scholar
Tsegos, I. K. & Ekdawi, M. Y. (1974) Double-blind controlled comparison of imipramine and viloxazine in depression. Current Medical Research and Opinion, 2, 455–60.Google Scholar
Uhlenhuth, E. G. & Park, L. C. (1964) The influence of medication (imipramine) and doctor in relieving depressed psychoneurotic outpatients. Journal of Psychiatric Research, 2, 101–22.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.