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Ventricular Size and CSF Transmitter Metabolite Concentrations in Severe Endogenous Depression

Published online by Cambridge University Press:  29 January 2018

H. M. A. S. Standish-Barry ,
N. Bouras ,
A. S. Hale ,
P. K. Bridges  and
J. R. Bartlett
H. M. A. S. Standish-Barry*
Affiliation:
University of Leeds, Clinical Sciences Building, St James's University Hospital, Leeds LS9 7TF
N. Bouras
Affiliation:
Guy's Hospital Medical School, London SE1 9RT
A. S. Hale
Affiliation:
Guy's Hospital, London SE1 9RT
P. K. Bridges
Affiliation:
Guy's Hospital, Brook General Hospital, Bexley Hospital. Guy's Hospital Medical School, London SE1 9RT
J. R. Bartlett
Affiliation:
Regional Neurosurgical Centre, Brook General Hospital, Shooters Hill, London SE18 4LW
*
∗Correspondence
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Abstract

The relationship between neurotransmitter metabolite concentrations and measurements of ventricular size on CAT scans and pneumoencephalographs was investigated in 15 patients with severe affective disorder. An association was identified between reduced levels of plasma free tryptophan and ventricular enlargement and also between raised ventricular CSF levels of 5 HIAA and ventricular enlargement.

Type
Papers
Information
The British Journal of Psychiatry , Volume 148 , Issue 4 , April 1986 , pp. 386 - 392
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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