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Urinary Excretion of Cyclic Amp and Manic-Depressive Psychosis

Published online by Cambridge University Press:  29 January 2018

B. L. Brown ,
J. G. Salway ,
J. D. M. Albano ,
R. P. Hullin  and
R. P. Ekins
B. L. Brown
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital Medical School, London, W1N 7RL
J. G. Salway
Affiliation:
Biochemistry Department, University of Leeds, Leeds, LS2 9LS
J. D. M. Albano
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital Medical School, London, W1N 7RL
R. P. Hullin
Affiliation:
Biochemistry Department, University of Leeds, Leeds, LS2 9LS
R. P. Ekins
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital Medical School, London, W1N 7RL
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Extract

Recently several communications have been published implicating impaired 3′5′ cyclic adenosine monophosphate (cyclic AMP) metabolism as a causal factor in affective disorders (1, 3, 7, 8, 9, 11). In particular, the urinary excretion of cyclic AMP in manic patients is reported to be increased compared with that of normal subjects, whereas in depressed patients a decreased excretion has been observed (1, 7, 8, 9). These findings form the basis of a theory explaining the systemic and mental symptoms of affective disorders (1).

Type
Papers
Information
The British Journal of Psychiatry , Volume 120 , Issue 557 , April 1972 , pp. 405 - 408
Copyright
Copyright © Royal College of Psychiatrists, 1972 

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References

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