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Urinary Cyclic AMP in ‘Endogenous' and ‘Neurotic’ Depression

Published online by Cambridge University Press:  29 January 2018

K. Sinanan ,
A. M. B. Keatinge ,
P. G. S. Beckett  and
W. Clayton Love
K. Sinanan
Affiliation:
St. Patrick's Hospital; Trinity College, Dublin; Cluain Mhuire Family Centre, Newtownpark Avenue, Blackrock, Co. Dublin
A. M. B. Keatinge
Affiliation:
Department of Clinical Biochemistry, Trinity College, Dublin
P. G. S. Beckett
Affiliation:
Trinity College, Dublin
W. Clayton Love
Affiliation:
Federated Dublin Voluntary Hospitals; Trinity College, Dublin
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Extract

Since the discovery of adenosine 3'5'-cyclic monophosphate (cyclic AMP) by Sutherland and Rall (1958), the concept has evolved that this nucleotide acts as the second messenger substance for many neurotransmitter and hormone-induced responses (Sutherland, Robison and Butcher, 1968). Cyclic AMP occurs in high concentration in the brain. Cyclic AMP is functionally closely related, and possibly fundamental, to the action of catecholamines and serotonin, both of which have been implicated in the amine hypothesis of depression (Granville-Grossman, 1971). Cyclic AMP is formed from ATP by the action of an enzyme adenyl cyclase, and it is degraded by the enzyme cyclic-AMP-phosphodiesterase (Lancet, Editorial, 1970) both of which occur in brain.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 126 , Issue 1 , January 1975 , pp. 49 - 55
Copyright
Copyright © Royal College of Psychiatrists, 1975 

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