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Urinary Creatinine in Drug-Excretion Studies in Chronic Schizophrenics

Published online by Cambridge University Press:  29 January 2018

S. Sved ,
A. Perales  and
H.-P. Houle
S. Sved
Affiliation:
Institut de Recherches Psychiatriques de Joliette, 1000, boul. Sainte-Anne, Joliette, Quebec, Canada
A. Perales
Affiliation:
Hospital del Nina, Av. Brasil 600, Lima, Peru
H.-P. Houle
Affiliation:
Institut de Recherches Psychiatriques de Joliette, 1000, boul. Sainte-Anne, Joliette, Quebec, Canada
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Extract

Creatinine has long been used as a basis for urinary excretion studies of drugs and metabolites. Nevertheless, the validity of this has been seriously challenged by Paterson (4), whose findings were confirmed by Scott and Hurley in adults (5) and by Applegarth, Hardwick and Ross in children (1). These authors found that evaluation of urinary creatinine output cannot replace the practice of careful timing of 24-hour specimens as a basis of excretion rate. However, collection of well-timed specimens in ambulant psychiatric patients usually presents a great deal of difficulty.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 120 , Issue 555 , February 1972 , pp. 219 - 222
Copyright
Copyright © Royal College of Psychiatrists, 1972 

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References

1 Applegarth, D. A., Hardwick, D. F., and Ross, P. M. (1968). ‘Creatinine excretion in children and the usefulness of creatinine equivalents in amino acid chromatography.’ Clinica Chimica Acta, 22, 131–4.CrossRefGoogle ScholarPubMed
2 Folin, O., and Wu, H. (1919). ‘A system of blood analysis.’ Journal of Biological Chemistry, 38, 81–110.CrossRefGoogle Scholar
3 Kalousek, G., Hlavacek, C., Nedoss, B., and Pollak, V. E. (1969). ‘Circadian rhythms of creatinine and electrolyte excretion in healthy pregnant women.’ American Journal of Obstetrics and Gynecology, 103, 856–67.CrossRefGoogle ScholarPubMed
4 Paterson, N. (1967). ‘Relative constancy of 24-hour urine volume and 24-hour creatinine output.’ Clinica Chimica Acta, 18, 57–8.CrossRefGoogle ScholarPubMed
5 Scott, P. J., and Hurley, P.J. (1968). ‘Demonstration of individual variation in constancy of 24-hour urinary creatinine excretion.’ Clinica Chimica Acta, 21, 411–14.CrossRefGoogle ScholarPubMed
6 Sved, S., Perales, A., and Palaic, D. (1971). ‘Chlorpromazine metabolism in chronic schizophrenics.’ British Journal of Psychiatry, 119, 589–96.CrossRefGoogle ScholarPubMed
7 Technicon Auto Analyzer Methodology (1963). Creatinine, N-lla. Form 350–11–2 R 6–3.Google Scholar
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