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Undifferentiated dementia, Alzheimer's disease and vascular dementia: Age- and gender-related incidence in Liverpool

The MRC–ALPHA Study

Published online by Cambridge University Press:  03 January 2018

J. R. M. Copeland ,
Cherie McCracken ,
M. E. Dewey ,
K. C. M. Wilson ,
Mark Doran ,
Chris Gilmore ,
Anne Scott  and
Bernie Larkin
J. R. M. Copeland*
Affiliation:
Department of Psychiatry, University of Liverpool, Royal Liverpool University Hospital, Liverpool
Cherie McCracken
Affiliation:
Department of Psychiatry, University of Liverpool, Royal Liverpool University Hospital, Liverpool
M. E. Dewey
Affiliation:
Nottingham Unit, Medical School, Queens Medical Centre, Nottingham
K. C. M. Wilson
Affiliation:
Academic Unit, EMI Directorate, St Catherines Hospital, Birkenhead
Mark Doran
Affiliation:
Department of Neurology and Neurosurgery, Walton Hospital, Walton, Liverpool
Chris Gilmore
Affiliation:
Wirral and West Cheshire Community NHS Trust, West Cheshire Hospital, Chester
Anne Scott
Affiliation:
Centre for Social Policy Research and Development, Bryn Afon, University of Wales, Bangor, Gwynedd
Bernie Larkin
Affiliation:
Stepping Hill Hospital, Stockport
*
Professor J. R. M. Copeland, Department of Psychiatry, University of Liverpool, Royal Liverpool University Hospital, Liverpool L69 3GA
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Abstract

Background

Does incidence of dementia follow the age pattern of prevalence? Is gender a risk factor? Do patterns of incidence differ between dementias?

Aims

To assess age-specific incidence rates of undifferentiated dementias, Alzheimer's disease and vascular dementia.

Method

5222 individuals aged $65 years, were interviewed using the Geriatric Mental State/History and Aetiology Schedule. The AGECAT package was used to identify cases at three interviewing waves at two-year intervals. Diagnoses were made using ICD −10 Research Criteria and validated against neurological and psychological examination, with imaging and neuropathology on unselected subsamples.

Results

Incidence rates of the dementias increase with age. Age patterns are similar between Alzheimer's disease and vascular dementia. Gender appears influential in Alzheimer's disease. In England and Wales, 39 437 new cases of Alzheimer's disease (4.9/1000 person-years at risk); 20 513 of vascular dementia (2.6/1000 person-years) and 155 169 of undifferentiated dementia (19/1000 person-years) can be expected each year.

Conclusions

Incidence rates for Alzheimer's disease and vascular dementia appear to behave differently with an increased risk of Alzheimer's disease for women compared to vascular dementia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 175 , Issue 5 , November 1999 , pp. 433 - 438
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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Footnotes

Declaration of interest

Funding was received from the Medical Research Council (UK), Lilly Industries and the Human Ageing Trust.

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