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Twin Birth and Adult Psychiatric Disorder

An examination of the Case Records of the Maudsley Hospital

Published online by Cambridge University Press:  02 January 2018

Bina Chitkara ,
Alison MacDonald  and
Adrianne M. Reveley
Bina Chitkara*
Affiliation:
Genetics Section, Institute of Psychiatry (Maudsley Hospital), De Crespigny Park, London SE5 8AF
Alison MacDonald
Affiliation:
Genetics Section, Institute of Psychiatry (Maudsley Hospital), De Crespigny Park, London SE5 8AF
Adrianne M. Reveley
Affiliation:
Genetics Section, Institute of Psychiatry (Maudsley Hospital), De Crespigny Park, London SE5 8AF
*
∗Correspondence
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Abstract

We compared the general distribution of diagnoses in 20 895 patients at the Maudsley Hospital with that of 504 patients born twins, including 117 twins where the co-twin had died before the age of 15. Significant differences in diagnostic distribution were found in the co-twin-dead compared with the co-twin-alive group; the former received diagnoses of schizophrenia, personality disorder, or substance abuse more often than the latter. While there were no overall differences between twins and non-twins, there were relatively more twins in the above three diagnostic groups. We suggest that the factors leading to the death of one twin are implicated in the later psychiatric morbidity of the survivor.

Type
Annotation
Information
The British Journal of Psychiatry , Volume 152 , Issue 3 , March 1988 , pp. 391 - 398
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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References

Bertelsen, A., Harvald, B. & Hauge, M. (1977) A Danish twin study of manic-depressive disorders. British Journal of Psychiatry, 130, 330–351.Google Scholar
Cloninger, C. R., Bohman, M. & Sigvardsson, S. (1981) Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Archives of General Psychiatry, 38, 861–868.CrossRefGoogle ScholarPubMed
DeLisi, L. E., Goldin, L. R. & Gershon, E. S. (1985) Subgroups in schizophrenia (letter). The Lancet, i, 1502.CrossRefGoogle Scholar
Department Of Psychiatry Teaching Committee, The Institute Of Psychiatry London (1973) Notes on Eliciting and Recording Clinical Information. Oxford: Oxford University Press.Google Scholar
Durkin, M. V., Kaveggia, E. G., Pendleton, E., Neuhauser, G. & Opitz, J. M. (1976) Analysis of ctiologic factors in cerebral palsy with severe mental retardation. European Journal of Pediatrics, 123, 67–81.Google Scholar
Farooqui, M. O. (1973) A review of twin pregnancy and perinatal mortality. Obstetrical and Gynecological Survey, 28, 144–153.Google Scholar
Farr, V. (1975) Prognosis for the babies, early and late. In Human Multiple Reproduction (eds MacGillivray, I., Nylander, P. P. S. & Corncy, G.), pp. 188–211. London: W. B. Saunders.Google Scholar
Fujikura, T. & Froehlich, L. A. (1971) Twin placentation and zygosity. Obstetrics and Gynecology, 37, 34–43.Google ScholarPubMed
Gittelman, M. & Birch, H. G. (1967) Childhood schizophrenia: intellect, neurologic status, perinatal risk, prognosis and family pathology, Archives of General Psychiatry, 17, 16–25.CrossRefGoogle ScholarPubMed
Gottesman, I. I. & Shields, J. (1972) Schizophrenia and Genetics: a Twin Study Vantage Point. New York and London: Academic Press.Google Scholar
Gurling, H. M. D., Oppenheim, B. E. & Murray, R. M. (1984a) Depression, criminality and psychopathology associated with alcoholism: evidence from a twin study. Acta Geneticae Medicae Gemellologiae Twin Research, 33, 333–339.Google Scholar
Gurling, H. M. D., Reveley, M. A. & Murray, R. M. (1984b) Increased cerebral ventricular volume in monozygotic twins discordant for alcoholism. The Lancet, i, 986–988.Google Scholar
Heady, J. A. & Heasman, M. A. (1959) Studies on Medical and Population Subjects No. 15. Social and Biological Factors in Infant Mortality, London: Her Majesty's Stationery Office.Google Scholar
Hoffman, H. J., Bakketeig, L. S. & Stark, C. R. (1978) Twins and perinatal mortality: a comparison between single and twin births in Minnesota and in Norway 1967–73. Progress in Clinical and Biological Research, 24b, 133–142.Google Scholar
Khoo, S. K. & Green, K. (1975) Twin pregnancies, influence of antenatal complications, hospital bed rest and misdiagnosis on prematurity and perinatal mortality. Australian and New Zealand Journal of Obstetrics and Gynaecology, 15, 84–92.CrossRefGoogle Scholar
Knobloch, H. & Pasamanick, B. (1966) Prospective studies on the epidemiology of reproductive casualty: methods, findings and some implications. Merrill Palmer Quarterly, 12, 27–43.Google Scholar
Knobloch, H. & Pasamanick, B. (1974) Some etiologic and prognostic factors in early infantile autism and psychosis. In Developmental Diagnosis (eds Knobloch, H. & Pasamanick, B.). Hagerstown, Maryland: Harper and Row.Google Scholar
Koivisto, M., Jouppila, P., Kauppila, A., Moilanen, I. & Ylikorkala, O. (1975) Twin pregnancy: neonatal morbidity and mortality. Acta Obstetricia et Gynecologica Scandinavica Supplement, 44, 21–29.CrossRefGoogle ScholarPubMed
Leetz, I. (1976) Twin pregnancy as a high risk pregnancy. Acta Geneticae Medicae Gemellologiae Twin Research, 25, 307–310.CrossRefGoogle ScholarPubMed
Leviton, A. & Gilles, F. H. (1984) Acquired perinatal leuko-encephalopathy. Annals of Neurology, 16, 1–8.CrossRefGoogle Scholar
Liechty, E. A., Gilmor, R. L., Bryson, C. Q. & Bull, M. J. (1983) Outcome of high-risk neonates with ventriculomegaly. Developmental Medicine of Child Neurology, 25, 162–168.CrossRefGoogle ScholarPubMed
McCarton-Daum, C., Danziger, A., Ruff, H. & Vaughan, H. S. (1983) Periventricular low density as a predictor of neuro-behavioural outcome in very low birthweight infants. Developmental Medicine and Child Neurology, 25, 559–565.CrossRefGoogle Scholar
McGue, M. Gottesman, I. I. & Rao, D. C. (1983) The transmission of schizophrenia under a multifactorial threshold model. American Journal of Human Genetics, 35, 1161–1178.Google Scholar
McNeil, T. F. & Kaij, L. (1978) Obstetric factors in the development of schizophrenia: complications in the births of preschizophrenics and in reproduction by schizophrenic parents. In The Nature of Schizophrenia (eds Wynne, L. C., Cromwell, R. L. & Matthysse, S.), pp. 401–429. New York: John Wiley & Sons.Google Scholar
Medearis, A. L., Jonas, H. S., Stockbauer, J. W. & Domke, H. (1979) Perinatal deaths in twin pregnancy. American Journal of Obstetrics and Gynaecology, 134, 413–418.Google Scholar
Mednick, S. A. (1974) Breakdown in individuals at high-risk for schizophrenia: possible predispositional perinatal factors. In Genetics, Environment and Psychopathology (eds Mednick, S. A., Schulsinger, F., Higgins, J. & Bell, B.), pp. 89–102. North Holland: American Elsevier.Google Scholar
Mednick, S. A. & Schulsinger, F. (1974) Studies of children at high risk for schizophrenia. In Genetics, Environment and Psychopathology (eds Mednick, S. A., Schulsinger, F., Higgins, J. & Bell, B.), pp. 103–116. North-Holland: American Elsevier.Google Scholar
Murray, R. M., Lewis, S. W. & Reveley, A. M. (1985) Towards an aetiological classification of schizophrenia. The Lancet, i, 1023–1026.CrossRefGoogle Scholar
Norman, M. G. (1982) Mechanisms of brain damage in twins. Canadian Journal of Neurological Sciences, 9, 339–344.CrossRefGoogle ScholarPubMed
Office of Population Censuses and Surveys (1970) Classification of Occupations. London: HMSO.Google Scholar
Pollack, M. & Greenberg, I. M. (1966) Paranatal complications in hospitalized schizophrenic and nonschizophrenic patients. Journal of Hillside Hospital, 15, 191–204.Google Scholar
Pollin, W. (1972) The pathogenesis of schizophrenia. Archives of General Psychiatry, 27, 29–37.Google Scholar
Pollin, W. & Stabenau, J. R. (1968) Biological, psychological and historical differences in a series of monozygotic twins discordant for schizophrenia. In The Transmission of Schizophrenia (eds Rosenthal, D. & Kety, S. S.). Oxford: Pergamon Press.Google Scholar
Potter, E. L. (1963) Twin zygosity and placental form in relation to the outcome of pregnancy. American Journal of Obstetrics and Gynecology, 87, 566–577.Google Scholar
Price, B. (1978) Bibliography on prenatal and natal influences in twins. Acta Geneticae Medicae et Gemellologiae Twin Research, 27, 97–113.Google Scholar
Reveley, A. M., Gurling, H. M. D. & Murray, R. M. (1981) Mortality and psychosis in twins. In Twin Research 3: Intelligence, Personality and Development, pp. 175–178. New York: Alan R. Liss Inc.Google Scholar
Reveley, A. M., Reveley, M. A., Clifford, C. A. & Murray, R. M. (1982) Cerebral ventricular enlargement in twins discordant for schizophrenia. The Lancet, i, 540–541.CrossRefGoogle Scholar
Reveley, A. M., Reveley, M. A. & Murray, R. M. (1984a) Cerebral ventricular enlargement in non-genetic schizophrenia: a controlled twin study. British Journal of Psychiatry, 144, 89–93.Google Scholar
Reveley, A. M., Reveley, M. A., Chitkara, B. & Clifford, C. A. (1984b) The genetic basis of cerebral ventricular volumne. Psychiatry Research, 13, 261–266.Google Scholar
Reveley, M. A. & Chitkara, B. (1985) Subtypes in schizophrenia (letter). The Lancet, i, 1503.Google Scholar
Rosenthal, D. (1960) Confusion of identity and the frequency of schizophrenia in twins. Archives of General Psychiatry, 3, 297–304.Google Scholar
Shaffer, D. (1977) Brain injury. In Child Psychiatry. Modern Approaches (eds Rutter, M. A Hersov, L.), pp. 185–215. Oxford: Blackwell Scientific Publications.Google Scholar
Shields, J. (1968) Psychiatric Genetics. In Studies in Psychiatry (eds Shepherd, M. and Davies, D. L.), pp. 168–191. London: Oxford University Press.Google Scholar
Stevens, J. R., Sachdev, K. & Milstein, V. (1968) Behavior disorders of childhood and the electroencephalogram. Archives of Neurology, 18. 160–177.Google Scholar
Tambyraja, R. L. & Ratnam, S. S. (1984) Factors contributing to a reduction of twin perinatal mortality in Singapore. Acta Geneticae Medicae Gamellologiae Twin Research, 33, 27–33.CrossRefGoogle ScholarPubMed
Thompson, W. D., Orvaschel, H. Prusoff, B. & Kidd, K. K. (1982) An evaluation of the family history method for ascertaining psychiatric disorders. Archives of General Psychiatry, 39, 53–58.Google Scholar
Werner, E. E. & Smith, R. S. (1982) Vulnerable, but Invincible: a Longitudinal Study of Resilient Children and Youth. New York: McGraw Hill.Google Scholar
Windham, G. C. & Bjerkedal, T. (1984) Malformations in twins and their siblings, Norway 1967–1979. Acta Geneticae Medicae et Gemellologiae Twin Research, 33, 87–95.Google Scholar
World Health Organization (1967) Manual of the International Statistical Classification of Diseases, Injuries, and Causes of Death, 1965 revision (8th edn) (ICD-8). Geneva: WHO.Google Scholar
World Health Organization (1978) Mental Disorders: Glossary and Guide to Their Classification in Accordance with the Ninth Revision of the International Classification of Diseases (ICD-9). Geneva: WHO.Google Scholar
Wyshak, G. & White, C. (1963) Birth hazard of the second twin. Journal of the American Medical Association, 186, 869–870.Google Scholar
Zahalkova, M. (1978) Perinatal and infant mortality in twins. Progress in Clinical and Biological Research, 24b, 115–120.Google Scholar
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