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A Trial of Bendrofluazide in Depression

Published online by Cambridge University Press:  29 January 2018

David Wheatley
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Extract

There is evidence that depression may be associated with retention of sodium, and on recovery electrolyte changes return to normal (Shaw, 1966; Elithorn et al., 1966). In the premenstrual syndrome, psychiatric symptoms commonly occur, particularly depression; together with fluid retention. Thiazide diuretics, which cause excretion of water, potassium and sodium, are an effective form of treatment of the syndrome. In consequence, it would seem logical to assess the effects of a thiazide diuretic given to depressed patients.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 123 , Issue 577 , December 1973 , pp. 713 - 714
Copyright
Copyright © Royal College of Psychiatrists, 1973 

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References

Elithorn, A., Bridges, P. K., Lobban, M. C., Tredre, B. E. (1966). ‘Observations on some diurnal rhythms in depressive illness.’ Brit. med. J., i, 391.Google Scholar
Shaw, D. M. (1966). ‘Mineral metabolism, mania and melancholia.’ Ibid., i, 262.Google Scholar
Wheatley, D. (1973). Psychopharmacology in Family Practice, Heinemann, London; and Appleton-Century-Crofts. New York.Google Scholar
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