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Testing the Effect of Season of Birth on Familial Risk for Schizophrenia and Related Disorders

Published online by Cambridge University Press:  02 January 2018

John M. Hettema ,
Dermot Walsh  and
Kenneth S. Kendler
John M. Hettema*
Affiliation:
Department of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA
Dermot Walsh
Affiliation:
Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA
Kenneth S. Kendler
Affiliation:
Health Research Board, Dublin and St. Loman's Hospital, Dublin, Ireland
*
Dr K. S. Kendler, Medical College of Virginia/VCU, P. O. Box 98710, Richmond, VA 23298–0710, USA
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Abstract

Background

An excess of late winter and early spring births in schizophrenia has been repeatedly demonstrated. Previous evidence has suggested that the risk for schizophrenia may differ in relatives of schizophrenic probands born in this high risk period v. at other times of the year.

Method

In an epidemiologically based family study conducted in the west of Ireland, we examined the relationship between season of birth in schizophrenia and schizophrenia spectrum probands and the risk for schizophrenia and related disorders in first-degree relatives. Risk was assessed using the Cox proportional hazard method. We examined four birth seasons previously shown to significantly predict risk for schizophrenia.

Results

Neither the risk for schizophrenia nor that for schizophrenia spectrum disorders in relatives was significantly associated with season of birth in probands.

Conclusions

Season of birth does not, in this sample, identify schizophrenic probands with particularly high or low familial vulnerability to illness.

Type
Papers
Information
The British Journal of Psychiatry , Volume 168 , Issue 2 , February 1996 , pp. 205 - 209
Copyright
Copyright © 1996 The Royal College of Psychiatrists 

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