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Tegretol (Carbamazepine): A Controlled Trial of a New Anti-Convulsant

Published online by Cambridge University Press:  29 January 2018

C. A. K. Bird ,
B. P. Griffin ,
J. M. Miklaszewska  and
A. W. Galbraith
C. A. K. Bird
Affiliation:
Macclesfield and District Hospitals
B. P. Griffin
Affiliation:
Cranage Hall Hospital, Holmes Chapel, Cheshire
J. M. Miklaszewska
Affiliation:
Cranage Hall Hospital, Holmes Chapel, Cheshire
A. W. Galbraith
Affiliation:
Geigy Pharmaceutical Company
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Extract

Tegretol (carbamazepine; 5-carbamyl-5H-dibenz (b, f) azepine) has been under investigation since 1958 in the treatment of epilepsy on the continent of Europe, following the demonstration of its anticonvulsant properties in animals by Theobald and Kunz (1963). Clinical reports have been enthusiastic (Lorgé, 1963, Bonduelle et al., 1963). The present investigation was undertaken with a view to a more critical appraisal of this drug, avoiding the dangers of sudden alteration of anticonvulsant therapy in epileptic patients, documented by Schwab et al. (1959), while still maintaining the double-blind nature of the trial.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 112 , Issue 488 , July 1966 , pp. 737 - 742
Copyright
Copyright © Royal College of Psychiatrists, 1966 

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References

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