Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-22T16:16:29.408Z Has data issue: false hasContentIssue false
  • English
  • Français

A Study of Refractory Cases of Depressive Illnesses and their Response to Combined Antidepressant Treatment

Published online by Cambridge University Press:  29 January 2018

E. R. Sethna
E. R. Sethna*
Affiliation:
All Saints' Hospital, Lodge Road, Birmingham B18 5SD
Get access Rights & Permissions [Opens in a new window]

Extract

Opinions differ on the effectiveness and the risk involved in treating depressive illnesses with combinations of monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants. Some authorities, including the Food and Drug Administration in the United States, the former Witts Committee in this country, and the pharmaceutical firms producing antidepressants, have given serious warnings against combining MAOIs with tricyclic antidepressants. These warnings have been repeated more recently by Beck (1967), Malitz (1966) and Shepherd et al. (1968).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 124 , Issue 580 , March 1974 , pp. 265 - 272
Copyright
Copyright © Royal College of Psychiatrists, 1974 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ayd, F. J. (1961). ‘Toxic somatic and psychopathologic reactions to antidepressant drugs.’ Journal of Neuropsychiatry, 2, 119–22.Google Scholar
Ayd, F. J. (1971). ‘Recognising and treating depressed patients’, in Modern Medicine, p. 80–86.Google Scholar
Babiak, J. (1961). ‘A case fatality of overdose of a combination of Parnate and Tofranil.’ Canadian Medical Association Journal, 85, 377–8.Google ScholarPubMed
Beck, A. T. (1967). Depression: Clinical, Experimental, and Theoretical Aspects, p. 304. New York.Google Scholar
Beresford Davies, E. (1963). ‘Combining the antidepressant drugs.’ Lancet, ii, 781–2.Google Scholar
Bowen, L. W. (1964). ‘Fatal hyperpyrexia with antidepressant drugs.’ British Medical Journal, ii, 1465.CrossRefGoogle Scholar
Brachfeld, J., Wintshaften, A., and Wolfe, S. (1963). ‘Imiprainme-tranylcyproinine incompatibility.’ Journal of American Medical Association, 186, 1172–3.Google ScholarPubMed
Chappell, A. G. (1966). ‘Severe hypothermia due to combination of psychotropic drugs and alcohol.’ British Medical Journal, i, 356.CrossRefGoogle Scholar
Ciocatto, E., Fagiano, G., and Bava, G. L. (1972). ‘Clinical features and treatment of overdosage of monoamine oxidase inhibitors and their interaction with other psychotropic drugs.’ Resuscitation, 1, 69–72.CrossRefGoogle ScholarPubMed
Dally, P. J. (1965). ‘Combining the antidepressant drugs.’ British Medical Journal, i, 384.CrossRefGoogle Scholar
Dally, P. J. (1967). Chemotherapy of Psychiatric Disorders, pp. 52–4. London.Google Scholar
Davies, G. (1960). ‘Side effects of phenelzine.’ British Medical Journal, ii, 1019.CrossRefGoogle Scholar
Gander, D. R. (1965). ‘Treatment of depressive illnesses with combined antidepressants.’ Lancet, ii, 107.CrossRefGoogle Scholar
Gander, D. R. (1967). ‘The clinical value of monoamine oxidase inhibitors and tricyclic antidepressants in combination’, in Proceedings of the First International Symposium on Antidepressant Drugs (ed. Ganathini, and Dukes, ), pp. 336–43. New York.Google Scholar
Grantham, J., Neel, W., and Brown, R. W. (1964). ‘Reversal of imipramine-monoamine oxidase inhibitor induced toxicity by chlorpromazine.’ Journal of Kansas Medical Society, 65, 279–80.Google ScholarPubMed
Guilmot, P., and Rucquoy, G. (1967). ‘Dangers in the too rapid substitution of imipramine for a monoamine oxidase inhibitor and in the combination of nialamine-isoniazid-barbiturates at high doses in psychiatric therapy.’ Acta Neurologica Belgica, 67, 159–71.Google ScholarPubMed
Hall, G. F. M. (1965). ‘Combining the antidepressant drugs.’ British Medical Journal, i, 383–4.Google Scholar
Hamilton, M. (1959). ‘The assessment of anxiety states by rating.’ British Journal of Medical Psychology, 32, 50–5.CrossRefGoogle ScholarPubMed
Hamilton, M. (1960). ‘A rating scale for depression.’ Journal of Neurology, Neurosurgery and Psychiatry, 23, 56–62.CrossRefGoogle ScholarPubMed
Harrer, G. (1961). ‘The incompatibility between monoamine oxidase inhibitors and imipramine.’ Wiener Medizinische Wochenschrift., 111, 551–3.Google Scholar
Hills, N. F. (1965). ‘Combining the antidepressant drugs.’ British Medical Journal, i, 859.CrossRefGoogle Scholar
Howarth, E. (1961). ‘Possible synergistic effects of the new thymoleptics in connection with poisoning.’ Journal of Mental Science, 107, 100–8.CrossRefGoogle ScholarPubMed
Hynes, B. (1965). ‘Combining the antidepressant drugs.’ British Medical Journal, i, 589.CrossRefGoogle Scholar
Jarecki, H. G. (1963). ‘Combined amitriptyline and phenelzine poisoning.’ American Journal of Psychiatry, 120, 189.CrossRefGoogle ScholarPubMed
Kane, F. J., and Freeman, D. (1963). ‘Non-fatal reaction to imipramine-MAO inhibitor combination.’ American Journal of Psychiatry, 120, 79–80.CrossRefGoogle ScholarPubMed
Lancet (1965). Leading article—‘Combining the antidepressant drugs.’ ii, 118.Google Scholar
Lee, F. (1961). ‘Imipramine overdosage—report of a fatal case.’ British Medical Journal, i, 338–9.Google Scholar
Lockett, M. F., and Milner, G. (1965). ‘Combining the antidepressant drugs.’ British Medical Journal, i, 921.CrossRefGoogle Scholar
Loveless, A. H., and Maxwell, D. R. (1965). ‘A comparison of the effects of imipramine, trimipramine, and some other drugs in rabbits treated with a monoamine oxidase inhibitor.’ British Journal of Pharmacology, 25, 158–70.Google ScholarPubMed
Luby, E. D., and Domino, E. F. (1961). ‘Toxicity from large doses of imipramine and on MAO inhibitor in a suicide attempt.’ Journal of the American Medical Association, 177, 68–9.Google Scholar
Malitz, S. (1966). ‘Drug therapy: Antidepressants’, in American Handbook of Psychiatry (ed. Arieti, ), 3, 493. New York.Google Scholar
Man, Pang L., and Aleem, , Ayten, (1972). ‘Are MAOI and other psychotropic drugs really compatible?’ British Journal of Psychiatry, 120, 120–1.CrossRefGoogle ScholarPubMed
McCurdy, R. L., and Kane, F. J. (1964). ‘Transient brain syndrome as a non-fatal reaction to combined pargyline imipramine treatment.’ American Journal of Psychiatry, 121, 397–8.CrossRefGoogle ScholarPubMed
Pare, C. M. B. (1965). ‘Treatment of depression.’ Lancet, i, 923–5.Google Scholar
Pare, C. M. B. (1965). ‘Combining the antidepressant drugs.’ British Medical Journal, i, 384.CrossRefGoogle Scholar
Randell, J. (1965). ‘Combining the antidepressant drugs.’ British Medical Journal, i, 521.CrossRefGoogle Scholar
Sargant, W. (1963). ‘Combining the antidepressant drugs.’ The Lancet, ii, 634.CrossRefGoogle Scholar
Sargant, W. (1965). ‘Antidepressant drugs.’ British Medical Journal, i, 1495.CrossRefGoogle Scholar
Sargant, W., Walter, C. J. S., and Wright, N. (1966). ‘New treatment of some chronic tension states.’ British Medical Journal, i, 322–4.Google Scholar
Sargant, W. (1967). ‘Psychotropic drugs.’ British Medical Journal, iii, 861.CrossRefGoogle Scholar
Sargant, W. (1967). ‘The treatment of depressive states.’ International Journal of Neurology, 6, 53–63.Google ScholarPubMed
Sargant, W. (1969). ‘Treatment of phobic anxiety state.’ British Medical Journal, iii, 118.CrossRefGoogle Scholar
Sargant, W. (1971). ‘Safety of combining antidepressant drugs.’ British Medical Journal, i, 555.CrossRefGoogle Scholar
Saunders, J. C. (1965). ‘Adverse drug reaction following treatment with monoamine oxidase inhibitors and imipramine and similar drugs.’ Journal of Kansas Medical Society, 66, 471–6.Google ScholarPubMed
Schuckit, M., Robins, E., and Feighner, J. (1971). ‘Tricyclic antidepressants and monoamine oxidase inhibitors: Combination therapy in the treatment of depression.’ Archives of General Psychiatry, 24, 509–14.CrossRefGoogle Scholar
Shepherd, M., Lader, M., and Rodknight, R. (1968). Clinical Psychopharmacology, p. 140. London.Google Scholar
Siegel, S. (1956). Nonparametric Statistics for the Behavioral Sciences. McGraw Hill Series in Psychology.Google Scholar
Simpson, G. M. (1972). ‘Combined antidepressant therapy.’ British Journal of Psychiatry, 120, 695.CrossRefGoogle Scholar
Singh, H. (1960). ‘Atropine-like poisoning due to tranquilizing agents.’ American Journal of Psychiatry, 117, 360–1.CrossRefGoogle Scholar
Stanley, B., and Pal, W. R. (1964). ‘Fatal hyperpyrexia with phenelzine and imipramine.’ British Medical Journal, ii, 1011.CrossRefGoogle Scholar
Steel, F., in Marks, J., and Pare, C. M. B. (1965). The Scientific Basis of Drug Therapy in Psychiatry, p. 203. London: Pergamon Press.Google Scholar
Watts, C. A. H. (1964). ‘Antidepressant drugs.’ British Medical Journal, i, 1114.CrossRefGoogle Scholar
Winston, F. (1971). ‘Combined antidepressant therapy.’ British Journal of Psychiatry, 118, 301–4.CrossRefGoogle ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.