The occurrence of psychiatric complications following the administration of ACTH and corticosteroids is well recognized. Psychiatric disturbances usually take the form of euphoria or elation in mood. Depression is less likely, and irritability or aggressiveness may occur. In about 5 per cent of cases the alteration in mood may be accompanied by clouding of consciousness, delusions, hallucinations and disorientation. This picture of an organic confusional state is said to result from high doses and prolonged therapy with corticosteroids and ACTH. The latter is recognized to cause psychiatric sequelae more often than the corticosteroids (Truelove and Witts, 1959). Disturbances may appear within six to seven hours of initial therapy (Goolker and Schein, 1953), after prolonged administration, or even after complete withdrawal of the hormone therapy.