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Spectrum Concept of Neuroleptic Malignant Syndrome

Published online by Cambridge University Press:  02 January 2018

Adityanjec ,
Suarn Singh ,
Gurnam Singh  and
Susan Ong
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Abstract

Although neuroleptic malignant syndrome (NMS) was initially thought to be a rare, idiosyncratic complication, the incidence estimates have been rising over the years. A part of this increase can be explained on the basis of an over-inclusive definition of NMS. The unitary concept of NMS has been challenged recently and a spectrum concept has been enunciated on the basis of findings of retrospective chart-reviews which have used too broad a definition of NMS. The authors describe three cases of neuroleptic-related toxicity with different clinical presentations which appeared in a manner apparently supporting the spectrum concept. They discuss this controversial concept critically, however, and caution against its overzealous use in routine clinical practice owing to its far-reaching clinical implications.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 153 , Issue 1 , July 1988 , pp. 107 - 111
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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References

Addonizio, G., Susman, V. L. & Roth, S. D. (1986) Symptoms of neuroleptic malignant syndrome in 82 consecutive inpatients. American Journal of Psychiatry, 143, 1587–1590.Google ScholarPubMed
Caroff, S. N. (1980) The neuroleptic malignant syndrome. Journal of Clinical Psychiatry, 41, 79–83.Google Scholar
Cohen, B. M., Baldessarini, R. J., Pope, H. G. & Lipinski, J. F. (1985) Neuroleptic malignant syndrome (letter). New England Journal of Medicine, 313, 1293.Google Scholar
Conlon, P. (1986) The spectrum concept of neuroleptic toxicity (letter). American Journal of Psychiatry, 143, 811.Google Scholar
Coons, D. J., Hillman, F. J. & Marshall, R. W. (1982) Treatment of neuroleptic malignant syndrome with dantrolene sodium: a case report. American Journal of Psychiatry, 139, 944–945.Google ScholarPubMed
Fogel, B. S. & Goldberg, R. J. (1985) Neuroleptic malignant syndrome (letter). New England Journal of Medicine, 313, 1292.Google Scholar
Goulon, M., Rohan-Chabot, P. de, Elkhaart, D., Gajados, P., Bismuth, C. & Conso, F. (1983) Beneficial effects of dantrolene in the treatment of neuroleptic malignant syndrome: a report of two cases. Neurology, 33, 516–518.Google Scholar
Guze, B. H. & Baxter, L. R. (1985a) Neuroleptic malignant syndrome. New England Journal of Medicine, 313, 163–166.Google Scholar
Guze, B. H. & Baxter, L. R. (1985b) Neuroleptic malignant syndrome. New England Journal of Medicine, 313, 1293.Google Scholar
Haggerty, J. J., Bensten, B. S. & Gillette, G. M. (1987) Neuroleptic malignant syndrome superimposed on tardive dyskinesia. British Journal of Psychiatry, 150, 104–105.Google Scholar
Levenson, J. L. (1985) Neuroleptic malignant syndrome. American Journal of Psychiatry, 142, 1137–1145.Google ScholarPubMed
Levenson, D. F. & Simpson, G. M. (1986) Neuroleptic-induced extrapyramidal symptoms with fever. Archives of General Psychiatry, 43, 839–848.Google Scholar
MacKay, A. V. P. (1982) Antischizophrenic drugs. In Drugs in psychiatric practice (ed. Tyrer, P. J.). Cambridge: Butterworth.Google Scholar
Misiaszek, J. J. & Potter, R. L. (1985) Atypical neuroleptic malignant syndrome responsive to conservative management. Psychosomatik, 26, 62–66.CrossRefGoogle ScholarPubMed
Mueller, P. S. (1985) Neuroleptic malignant syndrome. Psychosomatik, 26, 654–662.CrossRefGoogle ScholarPubMed
Pope, H. G., Keck, P. E. & McElroy, S. L. (1986) Frequency and presentation of neuroleptic malignant syndrome in a large psychiatric hospital. American Journal of Psychiatry, 143, 1227–1233.Google Scholar
Shalev, A. & Munitz, H. (1986) The neuroleptic malignant syndrome: agent and host interaction. Acta Psychiatrica Scandinavica, 73, 337–347.Google Scholar
Singh, G. (1981) The malignant neuroleptic syndrome (a review with report of three cases). Indian Journal of Psychiatry, 23, 179–183.Google Scholar
Tarsy, D. (1984) Movement disorders with neuroleptic drugs. Psychiatric Clinics of North America, 7, 453–471.Google Scholar
Weinberg, S. E. & Twerski, R. S. (1983) Neuroleptic malignant syndrome. Anesthesia and Analgesia, 62, 848–850.Google Scholar
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