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Spastic dysphonia and denervation signs in a young man with tardive dyskinesia

Published online by Cambridge University Press:  02 January 2018

Jeffrey A. Lieberman*
Affiliation:
School of Medicine, State University of New York at Stony Brook; Psychiatric Research, Hillside Hospital, division of Long Island Jewish Medical Center
Ross Reife
Affiliation:
School of Medicine, State University of New York at Stony Brook; Long Island Jewish Medical Center
*
Hillside Hospital, PO Box 38, Glen Oaks, NY 11004, USA

Abstract

Pathophysiological theories of tardive dyskinesia (TD) suggest the possibility of structural changes in the central nervous system of patients with TD. This report describes a case of choreoathetoid dyskinesia and spastic dysphonia associated with clinical and electromyographic signs of muscle denervation. The findings of this case suggest that the neurological syndrome originates within basal ganglia nuclei but may also extend to the peripheral neuromuscular system.

Type
Brief Reports
Copyright
Copyright © The Royal College of Psychiatrists 

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References

American Psychiatric Association (1980) Tardive Dyskinesia: Report of the American Psychiatric Association Task Force on Late Neurological Effects of Antipsychotic Drugs. Washington DC: APA.Google Scholar
Argoz, Z. & Mastaglia, F. (1979) Disorders of neuromuscular transmission caused by drugs. New England Journal of Medicine, 301, 409413.Google Scholar
Aronson, A. E. (1971) Early motor unit disease masquerading as psychogenic breathy dysphonia: a clinical case presentation. Journal of Speech and Hearing Disorders, 36, 115123.Google Scholar
Bond, W. S., Carvalho, M. & Foulks, E. F. (1982) Persistent dysarthria with apraxia associated with a combination of lithium carbonate and haloperidol. Journal of Clinical Psychiatry, 43, 256257.Google Scholar
Bradley, R., Dwyer, D., Kemp, A. T. & Crews, E. (1980) Antibodies against acetylcholine receptors in tardive dyskinesia. The Lancet, i, 320321.Google Scholar
Burke, R. E. (1984) Tardive dyskinesia: current clinical issues. Neurology, 34, 13481353.Google Scholar
Carpenter, M. & Sutin, J. (1983) Human Neuroanatomy (8th edn) (eds Carpenter, M. & Sutin, J.). Baltimore, Md: Williams and Wilkins.Google Scholar
Chiodo, L. A. & Bunney, B. S. (1983) Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons. Journal of Neuroscience, 3, 16071619.Google Scholar
Crayton, J. W. (1980) Neuromuscular pathophysiology in tardive dyskinesia. In Tardive Dyskinesia (ed. Fann, W.). Jamaica, New York: Spectrum Publications.Google Scholar
Drachman, D. B., Stanley, E. F., Pestronk, A., Griffin, J. W. & Price, D. L. (1982) Neurotrophic regulation of two properties of skeletal muscle by impulse-dependent and spontaneous acetylcholine transmission. Journal of Neuroscience, 2, 232243.Google Scholar
Gerlach, J., Reisby, N. & Randrup, N. (1974) Dopaminergic hypersensitivity and cholinergic hypofunction in the pathophysiology of TD. Psychopharmacology (Berlin), 34, 2135.Google Scholar
Gerratt, B. R., Goetz, C. G. & Fisher, H. B. (1984) Speech abnormalities in tardive dyskinesia. Archives of Neurology, 41, 273276.Google Scholar
Guth, I. (1968) Trophic influences of nerve on muscle. Physiological Reviews, 48, 645687.Google Scholar
Guth, I., Brown, W. C. & Ziemnowicz, J. D. (1981) Changes in cholinesterase activity of rat muscle during growth and hypertrophy. American Journal of Physiology, 211, 11131116.Google Scholar
Jellinger, K. (1977) Neuropathology findings after neuroleptic long-term therapy. In Neurotoxicity (eds Roizin, I., Shiraki, H. & Greevic, N.). New York: Raven Press.Google Scholar
Kane, J. M., Woerner, M., Borenstein, M., Wegner, J. & Lieberman, J. (1986) Integrating incidence and prevalence of tardive dyskinesia. Psychopharmacology Bulletin, 22, 254259.Google Scholar
Lieberman, J., Bradley, R., Rubenstein, M. & Kane, J. (1984) Antibodies to acetylcholine receptors in patients with tardive dyskinesia. The Lancet, i, 1066.Google Scholar
Lieberman, J., Kane, J., Johns, C. & Vital Herne, J. (1986) Clozapine – clinical evidence of novel effects. Clinical Neuropharmacology, 9, 140.Google Scholar
Lieberman, J., Pollack, S., Lesser, M. & Kane, J. (1988) Pharmacologic characterization of tardive dyskinesia. Journal of Clinical Psychopharmacology, 8, 254260.Google Scholar
Maxwell, S., Massengill, M. S. & Nashold, B. (1970) Tardive dyskinesia. Journal of Speech and Hearing Disorders, 35, 3336.Google Scholar
Moore, G. P. (1971) Voice disorders organically based. In Handbook of Speech Pathology and Audiology (ed. Travis, L. E.). Englewood Cliffs, NJ: Prentice-Hall.Google Scholar
Moss, H. B. & Green, A. (1982) Neuroleptic-associated dysphagia confirmed by esophageal manometry. American Journal of Psychiatry, 139, 515516.Google Scholar
Nevlud, G. N., Fann, W. E. & Falck, F. (1983) Acoustic parameters of voice and neuroleptic medication. Biological Psychiatry, 18, 10811084.Google Scholar
Nurnberg, H. G. & Greenwald, B. (1981) Stuttering: an unusual side effect of phenothiazines. American Journal of Psychiatry, 138, 386387.Google Scholar
Ravi, S. D., Borge, G. F. & Roach, F. L. (1982) Neuroleptics, laryngeal-pharyngeal dystonia, and acute renal failure. Journal of Clinical Psychiatry, 43, 300.Google Scholar
Rossi, G. & Cortesina, G. (1965) Multi-motor end-plate muscle fibres in the human vocalis muscle. Nature, 206, 629630.CrossRefGoogle ScholarPubMed
Saji, M. & Reis, D. J. (1987) Delayed transneuronal death of substantia nigra neurons prevented by y-aminobutyric acid agonist. Science, 235, 6669.Google Scholar
Seeger, T. F., Thal, L. & Gardner, E. L. (1982) Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: studies with chronic clozapine and haloperidol. Psychopharmacology, 76, 182187.Google Scholar
Solomon, K. (1977) Phenothiazine induced bulbar palsy-like syndrome and sudden death. American Journal of Psychiatry, 134, 308311.Google Scholar
Weiner, W. J., Goetz, C. G., Nausieda, P. A. et al (1978) Respiratory dyskinesias: extrapyramidal dysfunction and dyspnea. Annals of Internal Medicine, 88, 327331.Google Scholar
West, R. (1971) The neurophysiology of speech. In Handbook of Speech Pathology and Audiology (ed. Travis, L. E.). Englewood Cliffs, NJ: Prentice-Hall.Google Scholar
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