Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-05T09:00:24.205Z Has data issue: false hasContentIssue false
  • English
  • Français

Sex Concordance for Schizophrenia in Proband-relative Pairs

Published online by Cambridge University Press:  29 January 2018

Elizabeth Sturt  and
Eric Shur
Elizabeth Sturt
Affiliation:
MRC Social Psychiatry Unit, Institute of Psychiatry
Eric Shur
Affiliation:
Institute of Psychiatry, De Crespigny Park, London SE5 8AF
Get access Rights & Permissions [Opens in a new window]

Summary

Some hypotheses about the cause of schizophrenia are based on the puzzling tendency for mental illness to affect the same sex when two close relatives become psychiatrically ill. Sex-concordance rates were examined in 71 schizophrenic probands, who had at least one first-degree relative suffering from the same disorder, in order to test this tendency in a population of recently admitted patients. No unusual concordance rates were found when unaffected sibs were taken into account and relatives were stratified to take account of possible confounding factors. It would seem premature to construct hypotheses about the aetiology of schizophrenia based on evidence of this type.

Type
Papers
Information
The British Journal of Psychiatry , Volume 147 , Issue 1 , July 1985 , pp. 44 - 47
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Birch, M. W. (1964) The detection of partial association. I: the 2 x 2 case. Journal of the Royal Statistical Society, Series B, 26, 313–324.Google Scholar
Crow, T. J. (1983) Is schizophrenia an infectious disease? Lancet, i, 173–175.Google Scholar
Gottesman, I. I. & Shields, J. (1982) Schizophrenia: the epigenetic puzzle. Cambridge: Cambridge University Press.Google Scholar
Larson, C. A. & Nyman, G. E. (1973) Differential fertility in schizophrenia. Acta Psychiatrica Scandinavia, 49, 272–280.Google Scholar
Mantel, N. & Haenszel, W. (1959) Statistical aspects of the analysis of data from retrospective studies of diseases. Journal of the National Cancer Institute, 22, 719–748.Google Scholar
Mott, F. W. (1910) Hereditary aspects of nervous and mental disease. British Medical Journal, 2, 1013–1020.Google Scholar
Myerson, A. (1925) The inheritance of mental disease. Baltimore: Williams & Williams.Google Scholar
Penrose, L. S. (1942) Auxiliary genes for determining sex as contributory causes of mental illness. Journal of Mental Science, 88, 308–316.Google Scholar
Rosenthal, D. (1962) Familial concordance by sex with respect to schizophrenia. Psychological Bulletin, 59, 401–421.Google Scholar
Schultz, B. (1932) Zur Erbpathologie der Schizophrenic Zeitschrift für die gesamte Neurologie und Psychiatrie, 143, 175–293.Google Scholar
Shur, E. (1982) Season of birth in high and low genetic risk schizophrenics. British Journal of Psychiatry, 140, 410–415.Google Scholar
Tsuang, M. T. (1967) A study of pairs of sibs both hospitalised for mental disorder. British Journal of Psychiatry, 113, 283–300.Google Scholar
Zehnder, M. (1941) Über Kranheitsbild und Krankheitsverlauf bei schizophrenen Geschwistern. Monotschift für Psychiatrie und Neurologie, 103, 231–277.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.