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Severe Shock Caused by Chlorpromazine Hypersensitivity

Published online by Cambridge University Press:  29 January 2018

Pang L. Man  and
Calvin H. Chen
Pang L. Man
Affiliation:
Northville State Hospital, Northville, Michigan, 48167, U.S.A.
Calvin H. Chen
Affiliation:
Northville State Hospital, and Adjunct Assistant Professor of Psychiatry, Wayne State University, Detroit, Michigan
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Extract

The value of chlorpromazine in combating psychosis and its various symptoms has been firmly established in the last twenty years. The occurrence of sudden death and severe hypotensive reaction after being given the drug has been documented in the world literature (Kelly et al., 1963; Graupner et al., 1964; Rosati, 1964; Hollister et al., 1965; Grollman, 1965; Leestma et al., 1968).

Type
Research Article
Information
The British Journal of Psychiatry , Volume 122 , Issue 567 , February 1973 , pp. 185 - 187
Copyright
Copyright © Royal College of Psychiatrists, 1973 

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References

Gancro, R., and Wilder, R. (1970). ‘A mechanism of sudden death in chlorpromazine therapy.’ Amer. J. Psychiat., 127, 368–71.Google Scholar
Graupner, K. I., Murphree, O. D., and Meduna, L.J. (1964). ‘Electro-cardiographic changes associated with the use of thioridazine.’ J. Neuropsychiat., 5, 344–50.Google Scholar
Grollman, A. (1965). Pharmacology and Therapeutics. 6th ed. Philadelphia.Google Scholar
Hollxster, L. E., and Kosek, J. C. (1965). ‘Sudden death during treatment with phenothiazine derivatives.’ J. Amer. med. Assoc., 192, 1035–8.Google Scholar
Kelly, H. G., Fay, J. E., and Laverty, S. G. (1963). ‘Thioridazine hydrochloride: its effect on the electrocardiogram and a report of two fatalities, with electrocardiographic abnormalities.’ Canad. med. Assoc. J. 89. 546–54.Google Scholar
Leestma, J. E., and Koenig, K. L. (1968). ‘Sudden death and phenothiazines: a current controversy.’ Arch. gen. Psychiat., 18, 137–48.CrossRefGoogle Scholar
Rosati, D. (1964). ‘Hypotensive side effects of phenothiazines and their management.’ Dis. nerv. Syst., 25, 366–9.Google Scholar
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