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Schizophrenia with onset after age 50 years

2: Neurological, neuropsychological and MRI investigation

Published online by Cambridge University Press:  03 January 2018

Perminder Sachdev*
Affiliation:
School of Psychiatry, University of New South Wales and Neuropsychiatric Instihrte. The Prince of Wales Hospital, Sydney
Henry Brodaty
Affiliation:
School of Psychiatry, University of New South Wales and Academic Department of Psychogeriatrics, The Prince of Wales Hospital, Sydney
Noelene Rose
Affiliation:
Formerly School of Psychiatry, University of New South Wales and The Prince of Wales Hospital, Sydney
Stuart Cathcart
Affiliation:
Formerly School of Psychiatry, University of New South Wales and Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney
*
Dr P. S. Sachdev, NPI, The Prince of Wales Hospital, Randwick NSW 2031, Australia. Tel: +61-2-93823763; fax: +61-2-93823774; e-mail: [email protected]

Abstract

Background

Late-onset schizophrenia (LOS) may have a basis in age-related coarse brain disease, but empirical support for this is conflicting.

Aims

Is LOS characterised by more neurological disease than early-onset schizophrenia (EOS)?

Method

DSM–III–R–defined LOS subjects (n=27) were compared with 30 EOS and 34 volunteer control subjects on neurological status, neuropsychological test performance and brain magnetic resonance imaging (MRI)

Results

LOS and EOS groups had more ‘soft’ neurological signs and drug-induced movement abnormalities, and performed more poorly on tests assessing speed of information processing, memory and frontal executive functioning. On MRI, the LOS and EOS groups had greater lateral ventricular size than the control group. The LOS subjects also had more signal hyperintensities in periventricular white matter and subcortical nuclei than controls.

Conclusions

LOS and EOS subjects were very similar on neuropsychological, neurological and structural neuroimaging parameters, except that there were more MRI periventricular hyperintensities in LOS subjects.

Type
Papers
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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Footnotes

See Part 1, pp. 410–415. this issue.

Declaration of interest

The study was supported by the National Hearth and Medical Research Council of Australia and The Rebecca Cooper Foundation.

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