Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-31T14:54:43.841Z Has data issue: false hasContentIssue false
  • English
  • Français

Schizophrenia and Spectral Analysis of the Visual Evoked Potential

Published online by Cambridge University Press:  29 January 2018

J. W. Jutai ,
J. H. Gruzelier ,
J. F. Connolly ,
R. Manchanda  and
S. R. Hirsch
J. W. Jutai*
Affiliation:
Department of Psychiatry, Charing Cross Hospital Medical School, 24 St. Dunstans Road, London W6 8RP
J. H. Gruzelier
Affiliation:
Department of Psychiatry, Charing Cross Hospital Medical School
J. F. Connolly
Affiliation:
Department of Psychology, University of British Columbia, Vancouver, Canada
R. Manchanda
Affiliation:
Charing Cross Hospital Medical School
S. R. Hirsch
Affiliation:
Charing Cross Hospital Medical School
*
∗Correspondence.
Get access Rights & Permissions [Opens in a new window]

Summary

Power spectral analysis was performed on the visual evoked potentials (VEPs) recorded in response to flashes of different intensity in both unmedicated schizophrenic and normal subjects. At occipital locations (01, 02), schizophrenics showed less power than normals in the 10–14 Hz frequency range. In the 18–22 Hz range, schizophrenics showed under-activation in the left hemisphere and over-activation in the right. At temporal locations (T3, T4), schizophrenics showed abnormal (left greater than right) hemisphere patterns of activation in 10–14 Hz and 18–22 Hz ranges. There were no group differences in relationships between power and intensity changes at vertex (Cz). The results suggest abnormal cortical-subcortical interactions during analysis of visual information in schizophrenia.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 145 , Issue 5 , November 1984 , pp. 496 - 501
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Annett, M. (1967) The binomial distribution of right, mixed and left handedness. Quarterly Journal of Experimental Psychology, 19, 327–33.Google Scholar
Arseni, C., Crighel, E., Matei, M. & Dinu, M. (1979) Influence of temporal lobe lesions on photic-evoked responses in occipital visual areas. Applied Neurophysiology, 42, 145–52.Google Scholar
Bear, D. M. (1983) Commentary on P. Flor-Henry, Functional hemispheric asymmetry and psychopathology. Integrative Psychiatry, July–August, 46–52.Google Scholar
Buchsbaum, M. & Silverman, J. (1968) Stimulus intensity control and the cortical evoked response. Psychosomatic Medicine, 30, 12–22.Google Scholar
Connolly, J. & Gruzelier, J. (1982a) Amplitude and latency changes in the visual evoked potential (VEP) to different stimulus intensities. Psychophysiology, 19, 599–608.Google Scholar
Connolly, J. & Gruzelier, J. (1982b) A critical examination of augmenting/reducing methodology in schizophrenic patients and controls. In Advances in Biological Psychiatry, Vol. 9 (ed. Langau, ). Basel: Karger.Google Scholar
Connolly, J., Gruzelier, J., Manchanda, R. & Hirsch, S. R. (1983) Visual evoked potentials in schizophrenia: intensity effects and hemispheric asymmetry. British Journal of Psychiatry, 142, 152–5.Google Scholar
Davis, A. E. & Wada, J. A. (1977) Hemispheric asymmetries of visual and auditory information processing. Neuropsychologia, 15, 799–806.CrossRefGoogle ScholarPubMed
Dixon, W. J. (ed) (1973) BMD: Biomedical Computer Programmes. Berkeley: University of California Press.Google Scholar
Domino, E. F., Demetriou, S., Tuttle, T. & Klinge, V. (1979) Comparison of the visually evoked response in drug-free chronic schizophrenic patients and normal controls. Electroencephalography and Clinical Neurophysiology, 46, 123–7.Google Scholar
Flor-Henry, P. (1969) Psychoses and temporal lobe epilepsy: a controlled investigation. Epilepsia, 10, 363–395.Google Scholar
Flor-Henry, P. (1974) Psychosis, neurosis and epilepsy. British Journal of Psychiatry, 124, 144–50.Google Scholar
Giannitrapani, D. (1967) Developing concepts of lateralization of cerebral functions. Cortex, 3, 353–71.Google Scholar
Gruzelier, J. H. (1981) Cerebral laterality and psychopathology: Fact and Fiction. Psychological Medicine, 11, 219–27.Google Scholar
Gruzelier, J. H. (1973) Bilateral asymmetry of skin conductance orienting activity and levels in schizophrenia. Biological Psychology, 1, 21–41.Google Scholar
Gruzelier, J. H. & Manchanda, R. (1982) The syndrome of schizophrenia: Relations between electrodermal response, lateral asymmetries and clinical ratings. British Journal of Psychiatry, 141, 488–95.CrossRefGoogle ScholarPubMed
Henderson, V. W., Alexander, M. P. & Naeser, M. A. (1982) Right thalamic injury, impaired visuo spatial perception, and alexia. Neurology, 32, 235–40.Google Scholar
Itil, T. M. (1979) Computer analyzed EEG findings in adult schizophrenics, psychotic children and “high risk” children for schizophrenia. In Biological Psychiatry Today (eds. Obiols, J., Ballus, C., Gonzalez-Monclus, E. & Pujol, J.). Amsterdam: Elsevier.Google Scholar
Itil, T. M. Saletu, B. & Davis, S. (1972) EEG findings in chronic schizophrenics based on digital computer period analysis and analog power spectra. Biological Psychiatry, 5, 1–13.Google Scholar
Jutai, J. W., Gruzelier, J. H. & Connolly, J. F. (1984) Spectral analysis of the visual evoked potential (VEP): effects of stimulus luminance. Psychophysiology. In press.Google Scholar
Kleinman, J. E., Bridge, P., Karoum, F., Speciale, S., Staub, R., Zalcman, S., Gillin, J. C. & Wyatt, R. J. (1980) Chronic schizophrenia: Postmortem studies. In Perspectives in Schizophrenic Research (eds. Baxter, C. F. & Melnechuk, T.). New York: Raven Press.Google Scholar
Landau, S. G., Buchsbaum, M. S., Carpenter, W., Srauss, J. & Sacks, M. (1975) Schizophrenia and stimulus intensity control. Archives of General Psychiatry, 32, 1245–9.Google Scholar
Lansing, R. W. & Barlow, J. S. (1972) Rhythmic after activity to flashes in relation to the background alpha which precedes and follows the photic stimulus. Electroencephalography and Clinical Neurophysiology, 32, 149–60.Google Scholar
Marczynski, T. J. (1978) Neurochemical mechanisms in the genesis of slow potentials: A review and some clinical implications. In Multidisciplinary Perspectives in Event-related Brain Potential Research (ed. Otto, D. A.). Washington, D.C.: U.S. Government Printing Office.Google Scholar
Nogawa, T., Katayama, K., Tabata, Y., Ohshio, T. & Kawahara, T. (1976) Changes in amplitude of the EEG induced by a photic stimulus. Electroencephalography and Clinical Neurophysiology, 40, 78–88.Google Scholar
Ohmoto, T., Mimirus, Y., Baba, Y., Miyamoto, T., Matsumoto, Y., Nishimoto, A. & Matsumoto, K. (1978) Thalamic control of spontaneous alpha-rhythm and evoked responses. Applied Neurophysiology, 41, 188–92.Google Scholar
Oke, A. (1983) Norepinephrine distribution patterns in human thalamus. International Journal of Psychophysiology, 1, 109.Google Scholar
Oke, A. Keller, R., Mefford, L. & Adams, R. N. (1979) Lateralization of norepinephrine in humane thalamus. Science, 200, 1411–13.Google Scholar
Pfurtscheller, G., Aranibar, A. & Maresch, H. (1979) Amplitude of evoked potentials and degree of event-related desynchronization (ERD) during photic stimulation. Electroencephalography and Clinical Neurophysiology, 47, 21–30.Google Scholar
Rhodes, L. E., Dustman, R. E. & Beck, E. C. (1969) The visual evoked response: A comparison of bright and dull children. Electroencephalography and Clinical Neurophysiology, 27, 364–72.Google Scholar
Rhodes, L. E. Obitz, F. W. & Creel, D. (1975) Effect of alcohol and task on hemispheric asymmetry of visually evoked potentials in man. Electroencephalography and Clinical Neurophysiology, 38, 561–8.Google Scholar
Richlin, M., Weisinger, M., Weinstein, S., Giannini, M. & Morganstern, M. (1971) Interhemispheric asymmetries of evoked cortical responses in retarded and normal children. Cortex, 7, 98–105.Google Scholar
Sayers, B.McA., Foster, S., Beagley, H. A. & Ruggiero, C. (1983) EEG power variability and its relation to auditory-evoked cortical potentials. Medical Informatics, 8, 233–41.Google Scholar
Shagass, C. (1979) Psychiatric diagnostic correlates of evoked potentials. In Biological Psychiatry Today (eds. Obiols, J., Ballus, C., Gonzalez-Monchus, E. & Pujol, J.). Amsterdam: Elsevier.Google Scholar
Stevens, J. R. & Livermore, A. (1982) Telemetered EEG in schizophrenia: Spectral analysis during abnormal behaviour episodes. Journal of Neurology, Neurosurgery and Psychiatry, 45, 385–95.Google Scholar
Wilson, C. L., Babb, T. L., Halgren, E. & Crandall, P. H. (1983) Visual receptive fields and response properties of neurons in human temporal lobe and visual pathways. Brain, 106, 473–502.Google Scholar
Wing, J. K., Cooper, J. F. & Sartorious, N. (1974) The Measurement and Classification of Psychiatric Symptoms. London: Cambridge University Press.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.