Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-22T08:33:15.850Z Has data issue: false hasContentIssue false

A Review of Clinical Experience

Published online by Cambridge University Press:  29 January 2018

Andrew Skarbek
Affiliation:
Psycholinguistic Research Unit, University College London
Michael Jacobsen
Affiliation:
Clinical Evaluation Unit, The Bayer Products Company, Surbiton, Surrey

Extract

Oxypertine (also known as WIN 18,501–2) is a member of a new series of indolylalkylphenyl-piperazines synthesized by Archer et al (1). It resembles serotonin in respect of its indole nucleus, and the piperazine side-chain indicates a structural relationship with some of the major phenothiazines. Pharmacological studies by Wylie and Archer (17) showed oxypertine to have tranquillizing properties, and following preliminary human tolerance investigations (15) the psychotherapeutic nature of the agent was investigated by various workers in the United States and Europe.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1965 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Archer, S., Wylie, D. W., Harris, L. S., Lewis, T. R., Schulenberg, J. W., Bell, M. R., Kullnig, R. K., Arnold, A. (1962). “i-(indolylalkyl)-4-arylpiperazines: a new class of tranquillisers.” J. Amer. chem. Soc., 84, 1306.Google Scholar
Calwell, W. P. K., Jacobsen, M., Skarbek, A. (1964). “A comparative study of oxypertine and trifluoperazine in chronic schizophrenia—a new application of the Wing rating scale.” Brit. J. Psychiat., 110, 520–30.Google Scholar
Cole, J. O., Edwards, R. E.Prediction of clinical effects of psychotropic drugs from animal data.” (1964). Ciba Foundation Symposium: Animal Behaviour and Drug Action, p. 286. London: Churchill.Google Scholar
Durell, J., Pollin, W. (1963). “A trial on chronic schizophrenic patients of oxypertine, a psychotropic drug with an indole ring.” Brit. J. Psychiat., 109, 687–91.CrossRefGoogle ScholarPubMed
Flament, J., Lofft, J. G., von Mendelssohn, F. (1964). “Clinical investigation of psycho-pharmacological effects of Win 18,501–2.” Neuro-Psychopharmacology Proceedings: 3rd International Congress of Collegium Internationale Neuro-Psychopharmacologium, Munich, 1962, 3, 275. Amsterdam: Elsevier.Google Scholar
Frtedhopf, A. J., Hekimian, L. (1963). “A pilot study of Win 18,501.” Dis. Nerv. Syst., 24, 241–2.Google Scholar
Hamilton, M. (1961). Lectures on the Methodology of Clinical Research. London: Livingstone.Google Scholar
Hollister, L. E., Overall, J. E., Kimball, I., Bennet, J. L., Meyer, F., Caffey, E. (1963). “Oxypertine in newly admitted schizophrenics.” J. New Drugs, 3, 2631.Google Scholar
Lorr, M., Jenkins, R. L., Holsopple, J. Q. (1953). “The Multi-dimensional Scale for Rating Psychiatric Patients.” Veterans Administration Technical Bulletin, TB 10–507, November 16th, 1953, Washington.Google Scholar
Mahon, W. A., Daniel, E. E. (1964). “A method for the assessment of reports of drug trials.” Canad. med. Assoc. J., 90, 565–9.Google ScholarPubMed
Mainland, D. (1964). “The significance of ‘non-significance'.” Clin. Pharmacol. Therap., 4, 580–6.Google Scholar
Michaux, M. H., Hanlon, T. E., Ota, K. Y., Kurland, A. A. (1964). “Phenothiazines in the treatment of newly admitted State Hospital patients: global comparison of eight compounds in terms of an outcome index.” Curr. therap. Res., 6, 331–39.Google Scholar
Overall, J. E., Gorham, D. R. (1960). “The Brief Psychiatric Rating Scale.” Psychol. Rep., 10, 799.Google Scholar
Randrup, A., Munkvad, I. (1964). “On the relation of tryptaminic and serotenergic mechanisms to amphetamine-induced abnormal behaviour.” Acta. Pharmacol. et toxicol., 21, 272–82.Google Scholar
Sterling-Winthrop Research Institute. (1961). “A revised summary of experimental laboratory and preliminary clinical tolerance data on Win 18, 501–2.” New York.Google Scholar
Wing, J. K. (1961). “A simple and reliable sub-classification of chronic schizophrenia.” J. ment. Sci., 107, 862–75.CrossRefGoogle Scholar
Wyue, D. W., Archer, S. (1962). “Structure-activity relationships of 1-{(3-indolyl) alkyl}-4-aryl-piperazines, a new series of tranquillisers.” J. med. pharm. Chem., 5, 932–43.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.