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The Relationship Between Schizophrenia and Immigration are There Alternatives to Psychosocial Hypotheses?

Published online by Cambridge University Press:  02 January 2018

John M. Eagles*
Affiliation:
Royal Cornhill Hospital, Cornhill Road, Aberdeen AB9 2ZF

Abstract

Several recent studies have found markedly increased rates of schizophrenia among West Indian immigrants to the UK. Almost exclusively, authors have sought psychosocial explanations for these findings. This paper hypothesises that environmental causes, notably obstetric complications and perinatal infections, provide more plausible aetiological models, especially for the raised rates of schizophrenia among second-generation West Indian immigrants.

Type
Papers
Copyright
Copyright © 1991 The Royal College of Psychiatrists 

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References

Akinsola, H. A. & Fryers, T. (1986) A comparison of patterns of disability in severely mentally handicapped children of different ethnic origins. Psychological Medicine, 16, 127133.Google Scholar
Alvord, E. C., Jahnke, U., Fischer, E. N. J., et al (1987) The multiple causes of multiple sclerosis: the importance of age of infections in childhood. Journal of Child Neurology, 2, 313321.Google Scholar
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Batchelor, J. R. (1985) Immunological and pathological aspects. In McAlpine's Multiple Sclerosis (ed. Matthews, W. B.). Edinburgh: Churchill Livingstone.Google Scholar
Ben-Tovim, D. I. & Cushnie, J. M. (1986) The prevalence of schizophrenia in a remote area of Botswana. British Journal of Psychiatry, 148, 576580.Google Scholar
Birtchnell, J. (1971) Social class, parental social class, and social mobility in psychiatric patients and general population controls. Psychological Medicine, 1, 209221.Google Scholar
Burke, A. W. (1974) First admissions and planning in Jamaica. Social Psychiatry, 9, 3945.Google Scholar
Cannon, T. D., Mednick, S. A. & Parnas, J. (1989) Genetic and perinatal determinants of structural brain deficits in schizophrenia. Archives of General Psychiatry, 46, 883889.Google Scholar
Carlson, E. C. (1985) The impact of international migration upon the timing of marriage and childbearing. Demography, 22, 6172.Google Scholar
Carpenter, L. & Brockington, I. F. (1980) A study of mental illness in Asians, West Indians and Africans living in Manchester. British Journal of Psychiatry, 137, 201205.Google Scholar
Chung, R. K., Langeluddecke, P. & Tennant, C. (1986) Threatening life events in the onset of schizophrenia, schizophreniform psychosis and hypomania. British Journal of Psychiatry, 148, 680685.CrossRefGoogle ScholarPubMed
Cochrane, R. & Bal, S. S. (1987) Migration and schizophrenia: an examination of five hypotheses. Social Psychiatry, 22, 181191.Google Scholar
Cochrane, R. & Bal, S. S. (1989) Mental hospital admission rates of immigrants to England: a comparison of 1971 and 1981. Social Psychiatry and Psychiatric Epidemiology, 24, 211.CrossRefGoogle Scholar
Cooper, J. E., Goodhead, D., Craig, T., et al (1987) The incidence of schizophrenia in Nottingham. British Journal of Psychiatry, 151, 619629.Google Scholar
Crow, T. J. (1987) Integrated viral genes as potential pathogens in the functional psychoses. Journal of Psychiatric Research, 21, 479485.CrossRefGoogle ScholarPubMed
Dalen, P. (1988) Schizophrenia, season of birth and maternal age. British Journal of Psychiatry, 153, 727733.CrossRefGoogle ScholarPubMed
Dean, G., Walsh, D., Downing, H., et al (1981) First admissions of native born and immigrants to psychiatric hospitals in southeast England, 1976. British Journal of Psychiatry, 139, 506512.Google Scholar
DeLisi, L. E., Smith, S. B., Hamovit, J. R., et al (1986) Herpes simplex virus, cytomegalovirus and Epstein–Barr virus antibody titres in schizophrenic patients. Psychological Medicine, 16, 757763.Google Scholar
DeLisi, L. E., Goldin, L. R., Maxwell, M. E., et al (1987) Clinical features of illness in siblings with schizophrenia or schizoaffective disorder. Archives of General Psychiatry, 44, 891899.Google Scholar
Dunt, D. R. & Le Moine Parker, M. (1973) A computer data processing system for hospital obstetric records: obstetric complications in non-English speaking immigrants. Medical Journal of Australia, ii, 693698.Google Scholar
Eagles, J. M., Gibson, I., Bremner, M. H., et al (1990) Obstetric complications in DSM–III schizophrenics and their siblings. Lancet, 335, 11391141.Google Scholar
Flaherty, J. A. & Hoskinson, K. M. (1989) Cross-cultural research on schizophrenia and depression. Current Opinion in Psychiatry, 2, 3540.Google Scholar
Gillberg, C., Steffenburg, S., Borjesson, B., et al (1987) Infantile autism in children of immigrant parents: a population based study from Goteborg. British Journal of Psychiatry, 150, 856858.Google Scholar
Glover, G. R. (1989a) Why is there a high rate of schizophrenia in British Caribbeans? British Journal of Hospital Medicine, 42, 4851.Google Scholar
Glover, G. R. (1989b) Differences in psychiatric admission patterns between Caribbeans from different islands. Social Psychiatry and Psychiatric Epidemiology, 24, 209211.Google Scholar
Granville-Grossman, K. L. (1966) Birth order and schizophrenia. British Journal of Psychiatry, 112, 11191126.Google Scholar
Griffiths, R., White, M. & Stonehouse, M. (1989) Ethnic differences in birth statistics from central Birmingham. British Medical Journal, 298, 9495.Google Scholar
Gureje, O. & Adewunmi, A. (1988) Life events and schizophrenia in Nigerians: a controlled investigation. British Journal of Psychiatry, 153, 367375.Google Scholar
Halldin, J. (1985) Prevalence of mental disorder in an urban population in central Sweden in relation to social class, perinatal status and immigration. Acta Psychiatrica Scandinavica, 71, 117127.Google Scholar
Hare, E. H. (1979) Schizophrenia as an infectious disease. British Journal of Psychiatry, 135, 468473.Google Scholar
Hare, E. H. (1986) Aspects of the epidemiology of schizophrenia. British Journal of Psychiatry, 149, 554561.Google Scholar
Hare, E. H. (1987) Epidemiology of schizophrenia and affective psychoses. British Medical Bulletin, 43, 514530.Google Scholar
Hare, E. H. & Moran, P. A. P. (1979) Raised parental age in psychiatric patients: evidence for the constitutional hypothesis. British Journal of Psychiatry, 134, 169177.Google Scholar
Harlap, S. (1974) A time-series analysis of the incidence of Down's syndrome in West Jerusalem. American Journal of Epidemiology, 99, 210217.Google Scholar
Harrison, G., Owens, D., Holton, A., et al (1988) A prospective study of severe mental disorder in Afro-Caribbean patients. Psychological Medicine, 18, 643657.Google Scholar
Harrison, G., Holton, A., Neilson, D., et al (1989) Severe mental disorder in Afro-Caribbean patients: some social, demographic and service factors. Psychological Medicine, 19, 683696.Google Scholar
Iselius, L. & Lindsten, J. (1986) Changes in the incidence of Down syndrome in Sweden during 1968–82. Human Genetics, 72, 133139.Google Scholar
Jablensky, A. & Sartorius, N. (1988) Is schizophrenia universal? Acta Psychiatrica Scandinavica (suppl. 344), 6570.CrossRefGoogle ScholarPubMed
Jacobs, S. & Myers, J. (1976) Recent life events and acute schizophrenic psychosis: a controlled study. Journal of Nervous and Mental Disease, 162, 7587.Google Scholar
Jacobsen, B. & Kinney, D. K. (1980) Perinatal complications in adopted and non-adopted schizophrenics and their controls: preliminary results. Acta Psychiatrica Scandinavica (suppl. 285), 337346.CrossRefGoogle Scholar
Janerich, D. T. & Jacobsen, H. I. (1977) Seasonality in Down's Syndrome: an endocrinological explanation. Lancet, i, 515516.Google Scholar
Jongbloet, P. H., Mulder, A. & Hamers, A. J. (1982) Seasonality of preovulatory non-disjunction and the aetiology of Down's syndrome: a European collaborative study. Human Genetics, 62, 134138.Google Scholar
Jongbloet, P. J. N. (1971) Month of birth and gametopathy: an investigation into patients with Down's, Klinefelter's and Turner's syndrome. Clinical Genetics, 2, 315330.Google Scholar
Kendell, R. E. (1988) Schizophrenia. In Companion to Psychiatric Studies (eds Kendell, R. E. & Zealley, A. K.). Edinburgh: Churchill Livingstone.Google Scholar
Kendell, R. E. & Kemp, I. W. (1989) Maternal influenza in the aetiology of schizophrenia. Archives of General Psychiatry, 46, 878882.Google Scholar
Kerwin, R. W. (1989) How do the neuropathological changes of schizophrenia relate to pre-existing neurotransmitter and aetiological hypotheses? Psychological Medicine, 19, 563567.Google Scholar
King, D. J., Cooper, S. J., Earle, J. A. P., et al (1985) Serum and CSF antibody titres to seven common viruses in schizophrenic patients. British Journal of Psychiatry, 147, 145149.Google Scholar
King, D. J. & Cooper, S. J. (1989) Viruses, immunity and mental disorder. British Journal of Psychiatry, 154, 17.CrossRefGoogle ScholarPubMed
Kurtzke, J. F. (1983) Epidemiology of multiple sclerosis. In Multiple Sclerosis: Pathology, Diagnosis and Management (eds Hallpike, J. F., Adems, C. W. M. & Tourtellotte, W. W.). London: Chapman and Hall.Google Scholar
Lane, E. & Albee, G. W. (1966) Comparative birthweights of schizophrenics and their siblings. Journal of Psychiatry, 64, 227231.Google Scholar
Leff, J. (1987) A model of schizophrenic vulnerability to environmental factors. In Search for the Causes of Schizophrenia (eds Hafner, H., Gattaz, W. F. & Janzarik, W.). Berlin: Springer-Verlag.Google Scholar
Leff, J. (1988) What is the effect of migration? In Psychiatry Around the Globe: A Transcultural View. London: Gaskell.Google Scholar
Lewis, S. W. & Murray, R. M. (1987) Obstetric complications, neurodevelopmental deviance and risk of schizophrenia. Journal of Psychiatric Research, 21, 413421.Google Scholar
Lewis, S. W., Reveley, A. M., Reveley, M. A., et al (1987) The familial/sporadic distinction as a strategy in schizophrenia research. British Journal of Psychiatry, 151, 306313.Google Scholar
Littlewood, R. & Lipsedge, M. (1981) Acute psychotic reactions in Caribbean born patients. Psychological Medicine, 11, 303318.Google Scholar
Littlewood, R. & Lipsedge, M. (1988) Psychiatric illness among British Afro-Caribbeans. British Medical Journal, 296, 950951.Google Scholar
London, M. (1986) Mental illness among immigrant minorities in the United Kingdom. British Journal of Psychiatry, 149, 265273.Google Scholar
Lowis, G. W. (1988) Ethnic factors in multiple sclerosis: a review and critique of the epidemiological literature. International Journal of Epidemiology, 17, 1420.Google Scholar
Lumb, K. M., Congdon, P. J. & Lealman, G. T. (1981) A comparative review of Asian and British born maternity patients in Bradford, 1974–8. Journal of Epidemiology and Community Health, 35, 106109.Google Scholar
Machon, R. A., Mednick, S. A. & Schulsinger, F. (1987) Seasonality, birth complications and schizophrenia in a high risk sample. British Journal of Psychiatry, 151, 122124.Google Scholar
Malama, I. M., Apaioannou, D. J., Kaklamani, E. P., et al (1988) Birth order, sibship size and socio-economic factors in risk of schizophrenia in Greece. British Journal of Psychiatry, 152, 482486.Google Scholar
McGovern, D. & Cope, R. V. (1987) First psychiatric admission rate of first and second generation Afro Caribbeans. Social Psychiatry, 22, 139149.Google Scholar
Mednick, S. A., Machon, R. A., Huttanen, M. O., et al (1988) Adult schizophrenia following prenatal exposure to an influenza epidemic. Archives of General Psychiatry, 45, 189192.Google Scholar
Morrison, S. D. (1973) Intermediate variables in the association between immigration and mental illness. International Journal of Social Psychiatry, 19, 6065.Google Scholar
Murphy, H. B. M. (1977) Migration, culture and mental health. Psychological Medicine, 7, 677685.Google Scholar
Murray, R. M., Lewis, S. W. & Reveley, A. M. (1985) Towards an aetiological classification of schizophrenia. Lancet, i, 10231026.Google Scholar
Nimgaonkar, V. L., Wessely, S. & Murray, R. M. (1988) Prevalence of familiality, obstetric complications and structural brain damage in schizophrenic patients. British Journal of Psychiatry, 153, 191197.Google Scholar
North, A. F. & MacDonald, H. M. (1977) Why are neonatal mortality rates lower in small black infants than in white infants of similar birth weights? Journal of Pediatrics, 90, 809810.Google Scholar
Odegaard, O. (1932) Emigration and insanity: a study of mental disease among Norwegian-born population in Minnesota. Acta Psychiatrica et Neurologica Scandinavica, (suppl. 4).Google Scholar
Owen, M. J., Lewis, S. W. & Murray, R. M. (1988) Obstetric complications and schizophrenia: a computed tomographic study. Psychological Medicine, 18, 331339.Google Scholar
Parnas, J., Schulsinger, F., Teasdale, T. W., et al (1982) Perinatal complications and clinical outcome within the schizophrenic spectrum. British Journal of Psychiatry, 140, 416420.Google Scholar
Roos, R. P., Davis, K. & Meltzer, H. Y. (1985) Immunoglobulin studies in patients with psychiatric diseases. Archives of General Psychiatry, 42, 124128.Google Scholar
Royes, K. (1962) The incidence and features of psychoses in a Caribbean community. Proceedings of the 3rd World Congress of Psychiatry, 2, 11211125.Google Scholar
Sartorius, N., Jablensky, A., Korten, A., et al (1986) Early manifestations and first-contact incidence of schizophrenia in different cultures. Psychological Medicine, 16, 909928.Google Scholar
Schooler, C. (1961) Birth order and schizophrenia. Archives of General Psychiatry, 4, 9197.Google Scholar
Schwarzkopf, S. B., Nasrallah, H. A., Olson, S. C., et al (1989) Perinatal complications and genetic loading in schizophrenia: preliminary findings. Psychiatry Research, 27, 233239.Google Scholar
Shrikhande, S., Hirsch, S. R., Coleman, J. C., et al (1985) Cytomegalovirus and schizophrenia: a test of a viral hypothesis. British Journal of Psychiatry, 146, 503506.Google Scholar
Stabenau, J. R. & Pollin, W. (1967) Early characteristics of MZ twins discordant for schizophrenia. Archives of General Psychiatry, 17, 723734.Google Scholar
Stevens, J. R. (1987) Brief psychoses: do they contribute to the good prognosis and equal prevalence of schizophrenia in developing countries? British Journal of Psychiatry, 151, 393396.Google Scholar
Stevens, J. R. (1988) Schizophrenia and multiple sclerosis. Schizophrenia Bulletin, 14, 231241.Google Scholar
Stevens, J. R. & Wyatt, R. J. (1987) Similar incidence worldwide of schizophrenia: case not proven. British Journal of Psychiatry, 151, 131132.Google Scholar
Terry, P. B., Condie, R. G. & Settatree, R. S. (1980) Analysis of ethnic differences in perinatal statistics. British Medical Journal, 281, 13071308.Google Scholar
Terry, P. B., Condie, R. G., Bissenden, J. G., et al (1987) Ethnic differences in incidence of very low birthweight and neonatal deaths among normally formed infants. Archives of Disease of Childhood, 62, 709711.Google Scholar
Torrey, E. F. (1987a) Prevalence studies in schizophrenia. British Journal of Psychiatry, 150, 598608.Google Scholar
Torrey, E. F. (1987b) Similar incidence worldwide of schizophrenia: case not proven. British Journal of Psychiatry, 151, 132133.Google Scholar
Torrey, E. F., Torrey, B. B. & Burton-Bradley, B. G. (1974) Epidemiology of schizophrenia in Papua New Guinea. American Journal of Psychiatry, 131, 567573.Google Scholar
Torrey, E. F., Rawlings, R. & Waldman, I. N. (1988) Schizophrenic births and viral diseases in two states. Schizophrenia Research, 1, 7377.Google Scholar
Tuck, S. M., Cardozo, L. D., Studd, J. W. W., et al (1983) Obstetric characteristics in different racial groups. British Journal of Obstetrics and Gynaecology, 90, 892897.Google Scholar
Turner, S. W., Toone, B. K. & Brett-Jones, J. R. (1986) Computerised tomographic scan changes in early schizophrenia - preliminary findings. Psychological Medicine, 16, 219225.Google Scholar
Videbech, P. & Nielsen, J. (1984) Chromosome abnormalities and season of birth. Human Genetics, 65, 221231.Google Scholar
Watson, C. G., Kucala, T., Tilleskjor, C., et al (1984) Schizophrenic birth seasonality in relation to the incidence of infectious diseases and temperature extremes. Archives of General Psychiatry, 41, 8590.Google Scholar
Westermeyer, J. (1988) Resuming social approaches to psychiatric disorder: a critical contemporary need. Journal of Nervous and Mental Disease, 176, 703706.Google Scholar
Wilcox, J. A. & Nasrallah, H. A. (1987) Perinatal insult as a risk factor in paranoid and non-paranoid schizophrenia. Psychopathology, 20, 285287.Google Scholar
Wing, J. K. (1989) Schizophrenic psychoses: causal factors and risks. In The Scope of Epidemiological Psychiatry (eds Williams, P., Wilkinson, G. & Rawnsley, K.). London: Routledge.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) Measurement and Classification of Psychiatric Symptoms. London: Cambridge University Press.Google Scholar
World Health Organization (1968) Deliveries and complications of pregnancy, childbirth and the puerperium. World Health Statistics Report, 21, 468471.Google Scholar
World Health Organization (1978) Mental Disorders: Glossary and Guide to their Classification in Accordance with the Ninth Revision of the International Classification of Diseases (ICD–9). Geneva: WHO.Google Scholar
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