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The Relationship Between Extra- and Intracellular Lithium Concentration in Human Red Blood Cells: an in Vitro Study

Published online by Cambridge University Press:  29 January 2018

John J. Ratey
Affiliation:
From the Departments of Psychiatry and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Alan G. Mallinger*
Affiliation:
From the Departments of Psychiatry and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
*
Correspondence to be addressed to Dr Alan G. Mallinger, University of Pittsburgh, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, Pennsylvania 15261.

Summary

Red blood cells (RBCs) from normal volunteers were incubated in vitro at four different extracellular lithium concentrations. Extracellular lithium concentration affected RBC lithium accumulation in several ways. As extracellular lithium concentration increased, the inter-individual variability of RBC lithium accumulation increased. Furthermore, the ratio of RBC lithium concentration to extracellular lithium concentration (lithium ratio) increased in relation to increasing extracellular lithium concentration. A lack of agreement among the authors of recent reports dealing with the significance of the lithium ratio as a psychobiological measure has been noted. It is suggested that this lack of agreement may be due, in part, to the study of patients with differing levels of extracellular lithium.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1977 

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References

Cazzullo, C. L., Smeraldi, E., Sacchetti, E. & Bottinelli, S. (1975) Intracellular lithium concentration and clinical response. British Journal of Psychiatry, 126, 298300.Google Scholar
Dorus, E., Pandey, G. N. & Davis, J. M. (1975) Genetic determinant of lithium ion distribution: an in vitro and in vivo monozygotic-dizygotic twin study. Archives of General Psychiatry, 32, 1097–102.Google Scholar
Elizur, A., Shopsin, B., Gershon, S. & Ehlenberger, A. (1972) Intra : extracellular lithium ratios and clinical course in affective states. Clinical Pharmacology and Therapeutics, 13, 947–52.CrossRefGoogle ScholarPubMed
Knorring, L., Oreland, L., Perris, C. & Wiberg, A. (1976) Evaluation of the lithium RBC/plasma ratio as a predictor of the prophylactic effect of lithium treatment in affective disorders. Pharmakopsychiatrie Neuro Psychopharmakologie, 9, 81–4.CrossRefGoogle ScholarPubMed
Lee, C. R., Hill, S. E., Dimitrakoudi, M., Jenner, F. A. & Pollitt, R. J. (1975) The relationship of plasma to erythrocyte lithium levels in patients taking lithium carbonate. British Journal of Psychiatry, 127, 596–8.Google Scholar
Lyttkens, L., Söderberg, U. & Wetterberg, L. (1973) Relationen mellan intra- och exträcellulart litium som index vid psykisk sjukdom. Särtryck ur Nordisk Psykiatrisk Tidsskrift, 27, 392–7.Google Scholar
Mallinger, A. G., Kupfer, D. J., Poust, R. I. & Hanin, I. (1975) In vitro and in vivo transport of lithium by human erythrocytes. Clinical Pharmacology and Therapeutics, 18, 467–74.CrossRefGoogle ScholarPubMed
Mendels, J. & Frazer, A. (1973) Intracellular lithium concentration and clinical response: toward a membrane theory of depression. Journal of Psychiatric Research, 10, 918.Google Scholar
Mendels, J., Frazer, A., Baron, J., Kukopulos, A., Reginaldi, D., Tondo, L. & Caliari, B. (1976) Intra-erythrocyte lithium ion concentration and long-term maintenance treatment. Lancet, i, 966.Google Scholar
Ramsey, T. A., Frazer, A., Dyson, W. L. & Mendels, J. (1976) Intracellular lithium and clinical response. British Journal of Psychiatry, 128, 103–4.CrossRefGoogle ScholarPubMed
Rybakowski, J., Chlopocka, M., Kapelski, Z., Hernacka, B., Szajnerman, Z. & Kasprzak, K. (1974) Red blood cell lithium index in patients with affective disorders in the course of lithium prophylaxis. International Pharmacopsychiatry, 9, 166–71.Google Scholar
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