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Regional Cerebral Blood Flow in Patients with Affective Disorders

Published online by Cambridge University Press:  02 January 2018

V. Delvenne ,
F. Delecluse ,
Ph. P. Hubain ,
A. Schoutens ,
V. De Maertelaer  and
J. Mendlewicz
V. Delvenne
Affiliation:
Department of Psychiatry, Erasme Hospital
F. Delecluse
Affiliation:
Department of Nuclear Medicine, Erasme Hospital
Ph. P. Hubain
Affiliation:
Department of Psychiatry, Erasme Hospital
A. Schoutens
Affiliation:
Department of Nuclear Medicine, Erasme Hospital
V. De Maertelaer
Affiliation:
IRIBHN Statistical Unit, Free University of Brussels, Brussels, Belgium
J. Mendlewicz*
Affiliation:
Department of Psychiatry, Erasme Hospital, University Clinics of Brussels, Free University of Brussels, 808 route de Lennik, 1070 Brussels, Belgium
*
∗Correspondence
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Extract

Regional cerebral blood flow at rest was measured in 38 patients with major depressive disorders and 16 controls by SPECT with inhalation of xenon-133. All subjects had been withdrawn from medication. The mean hemispheric cerebral blood flow was not statistically different between the controls and the different subgroups of depressed patients defined either by biological markers or clinical characteristics. However, the predominantly cortical blood flow, measured on the outer cerebral rim of the third tomographic slice, was significantly lower on the left hemisphere in bipolar patients when compared with normals and unipolar patients. The same lateralisation was observed in patients with an endogenous depression according to the Newcastle scale.

Type
Papers
Information
The British Journal of Psychiatry , Volume 157 , Issue 3 , September 1990 , pp. 359 - 365
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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