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Regional Cerebral Blood Flow and Lateralized Hemispheric Dysfunction in Depression

Published online by Cambridge University Press:  29 January 2018

P. Uytdenhoef ,
P. Portelange ,
J. Jacquy ,
G. Charles ,
P. Linkowski  and
J. Mendlewicz
P. Uytdenhoef
Affiliation:
Hôpital Civil de Charleroi, 2 Boulevard Paul Janson, 6000 Charleroi, Belgium
P. Portelange
Affiliation:
Department of Isotopes, Hôpital Civil de Charleroi
J. Jacquy
Affiliation:
Department of Neurology, Hôpital Civil de Charleroi
G. Charles
Affiliation:
Hôpital Civil de Charleroi
P. Linkowski
Affiliation:
Hôpital Erasme, Free University of Brussels, 808 Route de Lennik, B-1070 Brussels
J. Mendlewicz
Affiliation:
Department of Psychiatry, Hôpital Erasme, Free University of Brussels, 808 Route de Lennik, 1070 Brussels
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Summary

Cerebral blood flow is known as an indicator of cerebral metabolism. Using the 133Xenon inhalation method, we studied the regional cerebral blood flow (r-CBF) in patients with different subtypes of depression and in remission. A left frontal hypervascularization and a right posterior hypovascularization were found in major depressives, compared to normal subjects, minor depressives, and normothymic bipolar patients. These results tend to confirm the existence of cerebral dysfunction in both hemispheres in major depression, as reported by other authors using different techniques.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 143 , Issue 2 , August 1983 , pp. 128 - 132
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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