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Quantitative Determination of Immunoglobulins in CSF and Plasma of Chronic Schizophrenic Patients

Published online by Cambridge University Press:  29 January 2018

Lynn E. Delisi ,
Daniel R. Weinberger ,
Steven Potkin ,
Leonard M. Neckers ,
David J. Shiling  and
Richard Jed Wyatt
Lynn E. Delisi
Affiliation:
Adult Psychiatry Branch, Division of Special Mental Research, Intramural Research Program, Saint Elizabeths Hospital, Washington, D.C. 20032, U.S.A.
Daniel R. Weinberger
Affiliation:
Adult Psychiatry Branch, Division of Special Mental Research, Intramural Research Program, Saint Elizabeths Hospital, Washington, D.C. 20032, U.S.A.
Steven Potkin
Affiliation:
Adult Psychiatry Branch, Division of Special Mental Research, Intramural Research Program, Saint Elizabeths Hospital, Washington, D.C. 20032, U.S.A.
Leonard M. Neckers
Affiliation:
Adult Psychiatry Branch, Division of Special Mental Research, Intramural Research Program, Saint Elizabeths Hospital, Washington, D.C. 20032, U.S.A.
David J. Shiling
Affiliation:
Adult Psychiatry Branch, Division of Special Mental Research, Intramural Research Program, Saint Elizabeths Hospital, Washington, D.C. 20032, U.S.A.
Richard Jed Wyatt
Affiliation:
Adult Psychiatry Branch, Division of Special Mental Research, Intramural Research Program, Saint Elizabeths Hospital, Washington, D.C. 20032, U.S.A.
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Summary

Immunoglobulins, IgG, IgA and IgM were quantified in cerebrospinal fluid (CSF) and plasma from chronic schizophrenic patients and controls using an immunofluorescent antibody technique. A generalized reduction in immunoglobulin levels was observed in the schizophrenic patients compared with controls. While this study supports other reports of abnormal immune functioning in schizophrenia, it failed to replicate previous findings of elevations in CSF IgG and elevations in serum IgA. The aetiology and significance of these findings are hypothesized but remain elusive.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 139 , Issue 6 , December 1981 , pp. 513 - 518
Copyright
Copyright © Royal College of Psychiatrists, 1981 

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