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Putative high risk for psychosis should not be considered a disorder

Published online by Cambridge University Press:  02 January 2018

David J. Castle*
Affiliation:
Department of Psychiatry, The University of Melbourne, PO Box 2900, Fitzroy, VIC 3065, Australia. Email: [email protected]
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Abstract

Type
Columns
Copyright
Copyright © Royal College of Psychiatrists, 2016 

The paper by Fusar-Poli and colleagues on functioning and quality of life (QoL) in people meeting supposed ‘high-risk’ status for psychosis Reference Fusar-Poli, Rocchetti, Sardella, Avila, Brandizzi and Caverzasi1 concludes, inter alia, that high-risk individuals do not differ statistically from individuals with established psychotic disorders in terms of QoL. This conclusion is used to help justify the views of the authors that ‘impairments in functioning and QoL are key features of the high-risk state’ (p. ) and that high risk is ‘not just a state of risk’ but a ‘disorder’ (in their title). However, reference to the original paper by Francey and colleagues Reference Francey, Jackson, Phillips, Wood, Yung and McGorry2 shows that QoL was actually higher in high-risk individuals than a first-episode psychosis comparison group. Thus the meta-analytic results shown in Fig. 2(b) of the paper by Fusar-Poli et al Reference Fusar-Poli, Rocchetti, Sardella, Avila, Brandizzi and Caverzasi1 are incorrect and, should the correct data be applied, would show that supposed high-risk individuals have overall better QoL than those with a ‘true’ psychotic illness.

Also of relevance in the study of Francey et al Reference Francey, Jackson, Phillips, Wood, Yung and McGorry2 was that QoL did not distinguish those high-risk individuals who supposedly transitioned to psychosis from those who did not, again throwing doubt on the views of Fusar-Poli et al that these supposed deficits reinforce the case for ‘prevention of transition’ (p. ) and ‘treatment of the current condition’. These latter ‘clinical implications’ are not, to my mind, supported by the data presented and disavow the fact that the majority of people supposedly at high risk for psychosis do not develop a psychotic illness and also that no treatment has consistently and replicably been shown to alter the likelihood of such transition. Reference Castle3 Hence, the assumption that the data presented should persuade us that the high-risk state is a ‘disorder’ or even a ‘condition’ is beyond me.

Finally, the authors attribute to me a view that high-risk individuals are ‘not at all dysfunctional’ (p. 200), but this is disingenuous: the point is that the supposed high-risk state is composed of a heterogeneous group of individuals and that many of them cannot be considered to have a ‘disorder’ in a heuristic, predictive or treatment sense.

References

1 Fusar-Poli, P, Rocchetti, M, Sardella, A, Avila, A, Brandizzi, M, Caverzasi, E, et al. Disorder, not just state of risk: meta-analysis of functioning and quality of life in people at high risk of psychosis. Br J Psychiatry 2015; 207: 198206.Google Scholar
2 Francey, SM, Jackson, HJ, Phillips, LJ, Wood, SJ, Yung, AR, McGorry, PD. Sustained attention in young people at high risk of psychosis does not predict transition to psychosis. Schizophr Res 2005; 79: 127–36.Google Scholar
3 Castle, DJ. Is it appropriate to treat people at high-risk of psychosis before first onset? Med J Australia 2012; 196: 557.Google Scholar
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