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Psychotoxic Effects of Benzhexol Hydrochloride (Artane)

Published online by Cambridge University Press:  29 January 2018

D. A. Stephens
D. A. Stephens*
Affiliation:
St. Luke's Hospital, Middlesbrough, Yorks
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Extract

Benzhexol hydrochloride (Artane, Pipanol, Trihexyphenidyl) was the first of a range of synthetic antispasmodic drugs to be made available for the symptomatic treatment of Parkinsonism. Selected as the most potent of a series of substituted piperidyl propanols examined pharmacologically by Cunningham et al. (1949), it was shown to have half the activity of atropine sulphate in inhibiting neurogenic spasm in isolated rabbit intestine. This activity was associated with advantageously reduced mydriatic, anti-sialogogic and vagal inhibitory properties in laboratory animals.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 113 , Issue 495 , February 1967 , pp. 213 - 218
Copyright
Copyright © Royal College of Psychiatrists, 1967 

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References

Abuse of Drugs (1964). Pharm. J. I., 262.Google Scholar
Bachrich, P. B. (1964). “New drugs of addiction.” Brit. med. J., i, 834.CrossRefGoogle Scholar
Bolin, R. R. (1960). “Psychiatric manifestations of artane toxicity.” J. nerv. ment. Dis., 131, 256–259.CrossRefGoogle Scholar
Bradley, P. B., and Elkes, J. (1957). In: Metabolism of the Nervous System. Ed. by Richter, D. London: Pergamon Press.Google Scholar
Connell, P. H. (1958). Amphetamine Psychosis. London: Chapman and Hall.Google Scholar
Critchley, M. (1958). “Drug treatment of parkinsonism.” Brit. med. J., ii, 1214–1215.CrossRefGoogle Scholar
Crossland, J. (1957). In: Metabolism of the Nervous System. Ed. Richter, D. London: Pergamon Press.Google Scholar
Cunningham, R. W. Harned, B. K., Clark, M. C., Cosgrove, R. R., Daugherty, N. S., Hine, C. H., Vessey, R. E., and Yuda, N. N. (1949). “The pharmacology of 3-(N-piperidyl)-1-phenyl-1-cyclohexyl-1-propanol hydrochloride (Artane) and related compounds.” J. Pharmacol. exp. Ther., 96, 151–165.Google Scholar
Doshay, L. J., Constable, K., and Zier, A. (1954). “Five year follow-up of treatment with trihexyphenidyl (Artane). Outcome in four hundred and eleven cases of paralysis agitans.” J. Amer. med. Ass., 154, 16, 1334–1336.CrossRefGoogle ScholarPubMed
Feldberg, W. (1957). In: Metabolism of the Nervous System. Ed. Richter, D. London: Pergamon Press.Google Scholar
Gooddy, W. (1959). “Time and the nervous system.” Lancet, ii, 1155–1156.CrossRefGoogle Scholar
Harris, T. H., and Torrens, J. K. (1950). “Use of artane in parkinsonism.” Texas State J. Med., 46, 514–515.Google ScholarPubMed
Katz, B., and Landis, C. (1935). “Psychologic and physiologic phenomena during a prolonged vigil.” Arch. Neurol. Psych., 34, 307–317.CrossRefGoogle Scholar
Miller, H. (1960). “The management of parkinsonism.” Practitioner, 184, 170–174.Google ScholarPubMed
Onuaguluchi, G. (1963). “Assessment of drug therapy in parkinsonism.” Brit. med. J., i, 443–448.CrossRefGoogle Scholar
Porteus, H. B., and Ross, D. N. (1956). “Mental symptoms in parkinsonism following benzhexol hydrochloride therapy.” Brit. med. J., ii, 138–140.CrossRefGoogle Scholar
Sherwood, S. (1957). In: Schizophrenia: Somatic Aspects. Ed. Richter, D. London: Pergamon Press.Google Scholar
Singh, S. P. (1961). “Benzhexol hydrochloride poisoning.” Brit. med. J., i, 130.CrossRefGoogle Scholar
Stephens, D. A. (1956). “Insanity unmasked.” J. of the Birmingham Medical School, 48, 3, 85–88.Google Scholar
World Health Organization (1958). “Ataractic and hallucinogenic drugs in psychiatry.” Tech. Report Series No. 152.Google Scholar
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