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Psychological and Clinical Investigation of the Treatment of Anxious Out-Patients with Three Barbiturates and Placebo

Published online by Cambridge University Press:  29 January 2018

Evelyn Reynolds ,
C. R. B. Joyce ,
J. L. Swift ,
P. H. Tooley  and
M. Weatherall
Evelyn Reynolds
Affiliation:
Department of Pharmacology, The London Hospital Medical College, Turner Street, E.1
C. R. B. Joyce
Affiliation:
Department of Pharmacology, The London Hospital Medical College, Turner Street, E.1
J. L. Swift
Affiliation:
Department of Psychiatry, The London Hospital, E.1
P. H. Tooley
Affiliation:
Department of Psychiatry, The London Hospital, E.1
M. Weatherall
Affiliation:
Department of Pharmacology, The London Hospital Medical College, E.1
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Extract

Barbiturates arc commonly used in treating anxious, disturbed patients. Well controlled trials have shown that at least amylobarbitone (‘Amytal’) is therapeutically active (Scott, 1955; Raymond, Lucas, Beesley, O'Connell and Fraser Roberts, 1957; Robin, 1959), and that a newer barbiturate, nealbarbitone (‘Censedal’) is, weight for weight, equally effective (Robin, Cronin and Scotton, 1961). Since nealbarbitone is less hypnotic (Ryde, 1959; Hinton, 1963), it may be used in larger doses than are expedient with amylobarbitone, and this could make it more useful in controlling anxiety. Phenobarbitone is widely used, especially in general practice, to relieve symptoms of anxiety. Its activity in experimental animals, for example in preventing electrically induced convulsions without causing sleep, differs considerably from that of amylobarbitone (Merritt and Putnam, 1938), but it appears not to have been compared directly with amylobarbitone in a controlled clinical trial upon patients with anxiety.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 470 , January 1965 , pp. 84 - 95
Copyright
Copyright © Royal College of Psychiatrists, 1965 

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References

Butler, T. C., Mahaffee, C., and Waddell, W. J. (1954). “Phenobarbital: studies of elimination, accumulation, tolerance and dosage schedules.” J. Pharmacol., 111, 425–435.Google Scholar
Finney, D. J. (1952). Statistical Method in Biological Assay, London: Griffin, pp. xix+661.Google Scholar
Fox, W. (1958). “The problem of self-administration of drugs, with particular reference to pulmonary tuberculosis.” Tubercle, 5, 269–274.Google Scholar
Gaddum, J. H. (1953). “Clinical pharmacology.” Proc. R. Soc. Med., 47, 195–204.Google Scholar
Heilizer, F. (1960). “A critical review of some published experiments with chlorpromazine in schizophrenic, neurotic and normal humans.” J. chron. Dis., 11, 102–148.Google Scholar
Hinton, J. M. (1963). “A comparison of the effects of six barbiturates and a placebo on insomnia and motility in psychiatric patients.” Brit. J. Pharmacol., 20, 319–325.Google Scholar
Joyce, C. R. B. (1958). “Measurement of reaction times with a conventional scaling unit.” J. Physiol., 141, 1–2P.Google Scholar
Joyce, C. R. B. (1959). “Consistent differences in individual reactions to drugs and dummies.” Brit. J. Pharmacol., 14, 512–521.Google Scholar
Joyce, C. R. B. (1962a). “Patient co-operation and the sensitivity of clinical trials.” J. chron. Dis., 15, 1025–1036.Google Scholar
Joyce, C. R. B. (1962b). “Differences between physicians as revealed by clinical trials.” Proc. Roy. Soc. Med., 55, 776–778.Google Scholar
Joyce, C. R. B. (1964). “What does the doctor let the patient tell him?” Proc. Soc. psychosomat. Res. In press Google Scholar
Klerman, G. L., DiMascio, A., Greenblatt, M., and Rinkel, M. (1959). “The influence of specific personality patterns on the reactions to phrenotropic agents”, in Biological Psychiatry (ed. Masserman, J.). New York: Grune & Stratton.Google Scholar
Kruskal, W. H., and Walle, W. A. (1952). “Use of ranks in one-criterion variance analysis.” J. Amer. Stat. Ass., 47, 583–621.Google Scholar
Laties, V. G., and Weiss, B. (1958). “A critical review of the efficacy of meprobamate (Miltown, Equanil) in the treatment of anxiety.” J. chron. Dis., 7, 500–519.Google Scholar
Mackworth, N. H. (1950). “Researches on the measurement of human performance.” Med. Res. Coun. spec. Rep. Ser., No. 268. London: H.M.S.O. Google Scholar
Mark, L. C. (1963). “Metabolism of barbiturates in man.” Clin. Pharmacol. Therap., 4, 504–530.CrossRefGoogle Scholar
Merritt, H. H., and Putnam, T. J. (1938). “A new series of anti-convulsant drugs tested by experiments on animals.” Arch. Neurol. Psychiat., 39, 1003–1015.Google Scholar
Myerscough, P. R., and Schild, H. O. (1958). “Quantitative assays of oxytocic drugs on the human postpartum uterus.” Brit. J. Pharmacol., 13, 207–212.Google Scholar
Nash, H. (1959). “The design and conduct of experiments on the psychological effects of drugs.” J. nerv. ment. Dis., 128, 129–147.Google Scholar
Raymond, M. J., Lucas, C. J., Beesley, M. L., O'Connell, B. A., and Fraser Roberts, J. A. (1957). “A trial of five tranquillizing drugs in psychoneurosis.” Brit. med. J., ii, 63–66.CrossRefGoogle Scholar
Robin, A. A. (1959). “Pecazine (‘Pacatal’) compared with amylobarbitone sodium in anxiety states.” J. Ment. Sci., 105, 1064–1069.Google Scholar
Robin, A. A., Cronin, D. P., and Scotton, L. (1961). “Clinical studies of a new barbiturate (Nealbarbitone).” Ibid., 107, 83–89.Google Scholar
Ryde, C. (1959). “Klinisk prövning av ett nytt sedativum.” Svenska lakartid., 56, 260–265.Google Scholar
Scott, P. A. L. (1955). “A controlled study of the effect of mephenesin on psychiatric out-patients.” J. Ment. Sci., 101, 163–171.Google Scholar
Sarwer-Foner, G. J. (1957). “The transference and nonspecific drug effects in the use of the tranquillizing drugs, and their influence on affect.” A.P.A. Psychiat. Res. Rep., 8, 153–167.Google Scholar
Smith, G. M., and Beecher, H. K. (1959). “Effect of morphine on the subjective response of hunger in normal subjects.” J. Pharmacol., 126, 63–69.Google Scholar
Sheard, M. H. (1963). “The influence of doctor's attitude on the patient's response to antidepressant medication.” J. nerv. merit. Dis., 136, 555–560.Google Scholar
Tooley, P. H. (1946). ‘Observations on psychiatry in the Royal Naval Patrol Service.’ Unpublished M.D. Thesis, University of London.Google Scholar
Trevan, J. W. (1927). “The error of determination of toxicity.” Proc. Roy. Soc. B., 101, 483–514.Google Scholar
Uhlenhuth, E. H., Canter, A., Neustadt, J. O., and Payson, H. E. (1959). “The symptomatic relief of anxiety with meprobamate, phenobarbital and placebo.” Amer. J. Psychiat., 115, 905–910.Google Scholar
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