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Psychiatric Illness Among Paternal and Maternal Relatives of Poor Prognosis Schizophrenics

Published online by Cambridge University Press:  29 January 2018

Michael S. Mccabe ,
Richard C. Fowler ,
Remi J. Cadoret  and
George Winokur
Michael S. Mccabe
Affiliation:
Aarhus Psychiatric Hospital, Institute of Psychiatric Demography, Risskov, Denmark
Richard C. Fowler
Affiliation:
Washington University School of Medicine, Department of Psychiatry, 4940 Audubon Avenue, St. Louis, Missouri 63110, U.S.A.
Remi J. Cadoret
Affiliation:
Washington University School of Medicine, Department of Psychiatry, 4940 Audubon Avenue, St. Louis, Missouri 63110, U.S.A.
George Winokur
Affiliation:
University of Iowa College of Medicine, Department of Psychiatry, 500 Newton Road, Iowa City, Iowa 52240, U.S.A.
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Extract

In 1966 Slater proposed a computational model for distinguishing polygenic inheritance and the effects of a single dominant gene. For a single dominant gene with diminished penetrance, affected relatives should be found predominantly on either maternal or paternal sides. He further proposed that to support a dominant gene hypothesis the ratio of unilaterally ill pairs to bilaterally ill pairs of relatives should exceed 2:1. ‘Unilateral pairs' means that there have been two or more ill relatives on either paternal or maternal sides; ‘bilateral pairs' that there has been at least one ill relative on each side.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 120 , Issue 554 , January 1972 , pp. 91 - 94
Copyright
Copyright © Royal College of Psychiatrists, 1972 

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