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Prolactin response to d-fenfluramine in obsessive-compulsive patients, and outcome of fluvoxamine treatment

Published online by Cambridge University Press:  03 January 2018

Palmiero Monteleone*
Affiliation:
Institute of Psychiatry, University of Naples, Italy
Francesco Catapano
Affiliation:
Institute of Psychiatry, University of Naples, Italy
Stefania Dl Martino
Affiliation:
Institute of Psychiatry, University of Naples, Italy
Ciro Ferraro
Affiliation:
Institute of Psychiatry, University of Naples, Italy
Mario Maj
Affiliation:
Institute of Psychiatry, University of Naples, Italy
*
Palmiero Monteleone, Clinica Psichiatrica, Primo Policlinico Universitario, Largo Madonna delle Grazie, 80138 Napoli, Italy

Abstract

Background

Although several studies have directly explored serotonin (5-HT) transmission in patients with obsessive compulsive disorder (OCD), their results have been inconsistent and their clinical relevance is doubtful

Method

According to a double-blind placebo-controlled design, plasma prolactin (PRL) response to a specific serotonergic probe, d-fenfluramine, was measured in 20 drug-free obsessive compulsive patients and in 20 matched healthy controls. After the neuroendocrine test, 5 patients completed a lO-week treatment with fluvoxamine. Psychopathological assessment was performed before and after therapy.

Results

PRL response in OCD patients was blunted under the drug-free condition; correlated inversely with pretreatment ratings of obsessive-compulsive and depressive symptomatology; and correlated inversely with the improvement in obsessive-compulsivescore observed after fluvoxamine treatment.

Conclusions

These results support the idea of a dysfunction of 5-HT transmission in OCD, and suggest that the greater this impairment, the better the response to drugs which selectively block the reuptake of 5-HT.

Type
Papers
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). Washington. DC: APA.Google Scholar
Bastani, B., Nash, F. & Meltzer, H. Y. (1990) Prolactin and cortisol responses to MK-2l2, a serotonin agonist. in obsessive-compulsive disorder. Archives of General Psychiatry, 47, 833839.Google Scholar
Goodman, W. K., Price, L. H., Rasmussen, S. A., et al (1989) The Yale-Brown Obsessive-compulsive Scale (Y-BOCS): I. Development. use and reliability. Archives of General Psychiatry 46, 10061011 CrossRefGoogle Scholar
Gorard, D. A., Taylor, T. M., Medbak, S. H., et al (1993) Plasma prolactin, adrenocorticotropic hormone and Cortisol after administration of d-fenfluramine or placebo in healthy subjects. International Clinical Psychopharmacology, 8, 123128.Google Scholar
Hamilton, M. A. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 5662.Google Scholar
Hollander, E., DéCaria, C. M., Nitescu, A., et al (1992) Serotonergic function in obsessive-compulsive disorder. Behavioral and neuroendocrine responses to oral m-chloro-phenylpiperazine and fenfluramine in patients and healthy volunteers. Archives of General Psychiatry 49, 2128.CrossRefGoogle Scholar
Lucey, J. V., O'Keane, V., Butcher, G., et al (1992) Cortisol and prolactin responses to d-fenfluramine in non-depressed patients with obsessive-compulsive disorder: a comparison with depressed and healthy controls. British Journal of Psychiatry, 161, 517521.Google Scholar
Lucey, J. V., O'Keane, V., Butcher, G., Butcher, G., Clare, A. W., et al (1993) The anterior pituitary responds normally to proterilin in obsessive -compulsive disorder: evidence to support a neuroendocrine serotonergic deficit. Acta Psychiatrica Scandinavica, 87, 384388.Google Scholar
McBride, P. A., Tierney, H., DeMeo, M., et al (1990) Effects of age and gender on CNS serotonergic responsivity in normal adults. Biological Psychiatry, 27, 11431155.CrossRefGoogle ScholarPubMed
O'Keane, V., O'Hanlon, M., Webb, M., et al (1991) Dfenfluramine/prolactin response throughout the menstrual cycle: evidence for an oestrogen-induced alteration. Clinical Endocrinology, 34, 289292.CrossRefGoogle Scholar
Roberts, A., Finberg, N. A., Montgomery, S. A., et al (1996) Increased prolactin responses to d-fenfluramine in patients with obsessive-compulsive disorder. Journal of Psychopharmacology, 10 (suppl. 3), A 37.Google Scholar
Swedo, S. E., Leonard, H. L., Kruesi, M. J., et al (1992) Cerebrospinal fluid neurochemistry in children and adolescents with obsessive-compulsive disorder. Archives of General Psychiatry 49, 2936.Google Scholar
Thorén, P., Asberg, M., Bertllsson, L., et al(1980) Clomipramine treatment of obsessive-compulsivi disorder. 11. Biochemical aspects. Archives of General Psychiatry, 37, 12891294.Google Scholar
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