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Prevalence of the Fragile X Syndrome in an Institution for the Mentally Handicapped

Published online by Cambridge University Press:  29 January 2018

David A. Primrose ,
Rabia El-Matmati ,
Elizabeth Boyd ,
Christine Gosden  and
Marjorie Newton
David A. Primrose
Affiliation:
Royal Scottish National Hospital, Larbert, Scotland FK5 4EJ (retired 31 December 1984)
Rabia El-Matmati
Affiliation:
Duncan Guthrie Institute of Medical Genetics, Glasgow
Elizabeth Boyd*
Affiliation:
Duncan Guthrie Institute of Medical Genetics, Glasgow
Christine Gosden
Affiliation:
MRC Clinical and Population Cytogenetics Unit, Edinburgh and Honorary Senior Lecturer in Human Genetics, King's College Hospital, London SE5 9RS
Marjorie Newton
Affiliation:
MRC Clinical and Population Cytogenetics Unit, Edinburgh
*
∗Correspondence 27 March 1985
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Abstract

In an investigation to find the prevalence of the fragile X (Martin Bell) syndrome in a mental handicap hospital, chromosomal investigations were carried out in 196 males selected out of a total of 512, and also in 20 female patients who were related to some of the selected males. Fragile X cells were found in 41 of the males and two of the females; in 21 of the males it was associated with macro-orchidism. The overall prevalence in the hospital for males (8.0%) ranks this syndrome next in importance to Down's syndrome as a known cause for mental handicap.

Type
Papers
Information
The British Journal of Psychiatry , Volume 148 , Issue 6 , June 1986 , pp. 655 - 657
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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