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Prevalence of Benzodiazepine Abuse and Dependence In-Psychiatric In-Patients with Different Nosology

An Assessment of Hospital-Based Drug Surveillance Data

Published online by Cambridge University Press:  02 January 2018

L. G. Schmidt ,
R. Grohmann ,
B. Müller-Oerlinghausen ,
M. Otto ,
E. Rüther  and
B. Wolf
L. G. Schmidt*
Affiliation:
Department of Psychiatry, Free University of Berlin
R. Grohmann
Affiliation:
Department of Psychiatry, University of Munich
B. Müller-Oerlinghausen
Affiliation:
Laboratory of Clinical Psychopharmacology
M. Otto
Affiliation:
Department of Psychiatry, Free University of Berlin
E. Rüther
Affiliation:
Department of Psychiatry, University of Munich
B. Wolf
Affiliation:
Department of Psychiatry, University of Göttingen
*
∗Eschenallee 3, D-1000 Berlin 19 (West), Germany
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Abstract

Frequencies of abuse and dependence assessed continuously within a drug surveillance system were analysed as a contribution to risk-benefit evaluations of benzodiazepines (BZDs). In 4.7% of 15 296 patients admitted to psychiatric hospitals between 1980 and 1985, BZDs had been involved in some kind of abuse or dependence. Primary BZD dependence, defined as physical dependence on BZDs in patients who had not been dependent before, was observed in about 1% of admitted patients. Linking these data with psychiatric diagnoses revealed a high risk of primary BZD dependence for inpatients (11.8%) with anxiety neurosis (ICD-9, 300.0), and a lower risk for neurotic (300.4) and for endogenous depressives (296.1) (risk 3.7% and 2.7% respectively). Older age was also related to primary BZD dependence. For depressive inpatients, the risk was twice as high in females as in males. Anecdotal observations advocate more systematic investigation of the emotional effects of long-term therapy with BZDs.

Type
Papers
Information
The British Journal of Psychiatry , Volume 154 , Issue 6 , June 1989 , pp. 839 - 843
Copyright
Copyright © Royal College of Psychiatrists, 1989 

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References

Ahrens, S., Ranzow, W. T. & Kernbichler, A. (1986) Ergebnisse eines Medikamenten-Screening stationär aufgenommener Patienten in einer Psychiatrischen Universitätsklinik. Nervenarzt, 57, 532–537.Google Scholar
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn). Washington DC: APA.Google Scholar
Fleisch hacker, U. W., Barnas, C. & Hackenberg, B. (1986) Epidemiology of benzodiazepine-dependence. Acta Psychiatrica Scandinavica, 74, 80–83.Google Scholar
Garvey, M. J. & Tollefson, G. D. (1986) Prevalence of misuse of prescribed benzodiazepines in patients with primary anxiety disorder or major depression. American Journal of Psychiatry, 143, 1601–1603.Google ScholarPubMed
Greenblatt, D. J., Shader, R. J. & Kochweser, J. (1975) Psychotropic drug use in the Boston area: a report from the Boston Collaborative Drug Surveillance Program. Archives of General Psychiatry, 32, 518–521.Google Scholar
Grohmann, R., Hippius, H., Müller-Oerlinghausen, B., et al (1984) Assessment of adverse drug reactions in psychiatric hospitals. European Journal of Clinical Pharmacology, 26, 727–734.Google Scholar
Hasin, D., Endicott, J. & Lewis, C. (1985) Alcohol and drug abuse in patients with affective syndromes. Comprehensive Psychiatry, 26, 283–295.Google Scholar
Krieg, J. C., Bronisch, T., Wittchen, H. U. & von Zerssen, D. (1987) Anxiety disorders: a long-term prospective and retrospective follow-up study of former inpatients suffering from an anxiety neurosis or phobia. Acta Psychiatrica Scandinavica, 76, 36–47.CrossRefGoogle ScholarPubMed
Koenig, W., Rüther, E., Remmers, A. & Keil, U. (1987) Comparison of psychotropic drug intake in two populations in West Germany: results from the Munich Blood Pressure Study 1980/81 and the Lübeck Blood Pressure Study 1984. Pharmacopsychiatry, 20, 111–115.CrossRefGoogle Scholar
Lader, M. (1983) Dependence on benzodiazepines. Journal of Clinical Psychiatry, 44, 121–127.Google Scholar
Lader, M. & File, S. (1987) The biological basis of benzodiazepine dependence. Psychological Medicine, 17, 539–547.Google Scholar
Laux, G. & König, W. (1987) Long-term use of benzodiazepines in psychiatric inpatients. Acta Psychiatrica Scandinavica, 76, 64–70.Google Scholar
Lydiard, R. B., Laraia, M. T., Ballenger, J. C., et al (1987) Emergence of depressive symptoms in patients receiving alprazolam for panic disorder. American Journal of Psychiatry, 144, 664–665.Google ScholarPubMed
Marks, J. (1978) The Benzodiazepines: Use, Overuse, Misuse, Abuse. Lancaster: MTP-Press.Google Scholar
Mellinger, G. D., Balter, M. B., Manheimer, D. I., et al (1978) Psychic distress, life crisis, and use of psychotherapeutic medications. Archives of General Psychiatry, 35, 1045–1052.Google Scholar
Müller-Oerlinghausen, B. (1986) Prescription and misuse of benzodiazepines in Germany. Pharmacopsychiatry, 19, 8–13.Google Scholar
Murray, J., Dunn, G., Williams, P., et al (1981) Factors affecting the consumption of psychotropic drugs. Psychological Medicine, 11, 551–560.Google Scholar
Olajide, D. & Lader, M. (1984) Depression following withdrawal from long-term benzodiazepine use: a report of four cases. Psychological Medicine, 14, 937–940.Google Scholar
Petursson, H. & Lader, M. H. (1981) Benzodiazepine-dependence. British Journal of Addiction, 76, 133–145.CrossRefGoogle ScholarPubMed
Poser, W. & Poser, S. (1986) Abusus und Abhängigkeit von Benzodiazepinen. Internist, 27, 738–745.Google Scholar
Schmidt, L. G. Grohmann, R., Müller-Oerlinghausen, B., et al (1986a) Adverse drug reactions of first and second generation antidepressants – a critical evaluation of drug surveillance data. British Journal of Psychiatry, 148, 38–43.CrossRefGoogle ScholarPubMed
Schmidt, L. G., Dirschedl, P., Grohmann, R., et al (1986b) Consistency of assessing adverse drug reactions in psychiatric hospitals: a comparison of an algorithmic and an empirical approach. European Journal of Clinical Pharmacology, 30, 199–204.CrossRefGoogle Scholar
Schmidt, L. G., Lammers, V., Stöckel, M., et al (1988) Recent trends in prescribing psychotropic drugs at a university hospital (1981–84). Pharmacopsychiatry, 21, 126–130.CrossRefGoogle Scholar
Tyrer, P., Rutherford, D. & Hugget, T. (1981) Benzodiazepine withdrawal syndrome and propanolol. Lancet, i 520–522.Google Scholar
Tyrer, P. & Murphy, S. (1987) The place of benzodiazepines in psychiatric practice. British Journal of Psychiatry, 151, 719–723.CrossRefGoogle ScholarPubMed
Williams, P., Murray, J. & Clare, A. (1982) A longitudinal study of psychotropic drug prescription. Psychological Medicine, 12, 201–206.Google Scholar
Wolf, B. & Rüther, E. (1984) Benzodiazepin-Abhängigkeit. Münchner Medizinische Wochenschrift, 126, 294–296.Google Scholar
World Health Organization (1965) Committee on Dependence-Producing Drugs. Technical Report Series. Geneva: WHO.Google Scholar
World Health Organization (1978) Mental Disorders: Glossary and Guide to their Classification in Accordance with the Ninth Revision of the International Classification of Diseases. (ICD–9). Geneva: WHO.Google Scholar
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